Human Follicle-Stimulating Hormone Complexed with its Receptor: Difference between revisions
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[[Image:1xwd.png|left|200px]] | [[Image:1xwd.png|left|200px]] | ||
===Crystal Structure of Human Follicle-Stimulating Hormone Complexed with its Receptor=== | |||
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==Disease== | |||
Known disease associated with this structure: Follicle-stimulating hormone deficiency, isolated OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=136530 136530]], Ovarian dysgenesis 1 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=136435 136435]], Ovarian hyperstimulation syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=136435 136435]], Ovarian response to FSH stimulation OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=136435 136435]], Ovarian sex cord tumors OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=136435 136435]] | |||
==About this Structure== | |||
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{{Button ColorReceptorLeucine}} <scene name='Human_Follicle-Stimulating_Hormone_Complexed_with_its_Receptor/1fl7to1xwdmorph/1'>Initial scene</scene> | {{Button ColorReceptorLeucine}} <scene name='Human_Follicle-Stimulating_Hormone_Complexed_with_its_Receptor/1fl7to1xwdmorph/1'>Initial scene</scene> | ||
</center></td></tr></table> | </center></td></tr></table> | ||
1XWD is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XWD OCA]. | 1XWD is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XWD OCA]. | ||
The leucine-rich domain of the receptor <scene name='Human_Follicle-Stimulating_Hormone_Complexed_with_its_Receptor/1fl7to1xwdmorphleu/1'>has a characteristic bowed shape due to harboring a series of leucine-rich repeats</scene>; [[leucine-rich repeats]] often are horseshoe- or arc-shaped. | The leucine-rich domain of the receptor <scene name='Human_Follicle-Stimulating_Hormone_Complexed_with_its_Receptor/1fl7to1xwdmorphleu/1'>has a characteristic bowed shape due to harboring a series of leucine-rich repeats</scene>; [[leucine-rich repeats]] often are horseshoe- or arc-shaped. | ||
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==Reference== | ==Reference== | ||
