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New page: left|200px<br /> <applet load="2v0f" size="450" color="white" frame="true" align="right" spinBox="true" caption="2v0f" /> '''BRK DOMAIN FROM HUMAN CHD7'''<br /> ==Over...
 
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[[Image:2v0f.gif|left|200px]]<br />
[[Image:2v0f.gif|left|200px]]<br /><applet load="2v0f" size="350" color="white" frame="true" align="right" spinBox="true"  
<applet load="2v0f" size="450" color="white" frame="true" align="right" spinBox="true"  
caption="2v0f" />
caption="2v0f" />
'''BRK DOMAIN FROM HUMAN CHD7'''<br />
'''BRK DOMAIN FROM HUMAN CHD7'''<br />
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==Overview==
==Overview==
CHD7 is a member of the chromodomain helicase DNA binding domain (CHD), family of ATP-dependent chromatin remodelling enzymes. It is mutated in, CHARGE syndrome, a multiple congenital anomaly condition. CHD7 is one of a, subset of CHD proteins, unique to metazoans that contain the BRK domain, a, protein module also found in the Brahma/BRG1 family of helicases. We, describe here the NMR solution structure of the two BRK domains of CHD7., Each domain has a compact betabetaalphabeta fold. The second domain has a, C-terminal extension consisting of two additional helices. The structure, differs from those of other domains present in chromatin-associated, proteins.
CHD7 is a member of the chromodomain helicase DNA binding domain (CHD), family of ATP-dependent chromatin remodelling enzymes. It is mutated in, CHARGE syndrome, a multiple congenital anomaly condition. CHD7 is one of a, subset of CHD proteins, unique to metazoans that contain the BRK domain, a, protein module also found in the Brahma/BRG1 family of helicases. We, describe here the NMR solution structure of the two BRK domains of CHD7., Each domain has a compact betabetaalphabeta fold. The second domain has a, C-terminal extension consisting of two additional helices. The structure, differs from those of other domains present in chromatin-associated, proteins.
==Disease==
Known diseases associated with this structure: CHARGE syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=608892 608892]], Scoliosis, idiopathic 3 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=608892 608892]]


==About this Structure==
==About this Structure==
2V0F is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2V0F OCA].  
2V0F is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V0F OCA].  


==Reference==
==Reference==
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[[Category: transcription regulation]]
[[Category: transcription regulation]]


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