Sandbox Reserved 349: Difference between revisions
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='''Porphobilinogen Deaminase'''= | ='''Porphobilinogen Deaminase'''= | ||
{{STRUCTURE_3eq1 | PDB=3eq1 | SCENE= }} | {{STRUCTURE_3eq1 | PDB=3eq1 | SCENE= }} | ||
Porphobilinogen deaminase (PBGD) also known as Hydroxymethylbilane synthase, is the third enzyme in the heme biosynthesis pathways in mammals<ref name="Raj">PMID: 19207107</ref>. It catalyses the polymerization of four porphobilinogen molecules to yield hydroxymethylbilane<ref name="Peter">PMID:3079571</ref> | Porphobilinogen deaminase (PBGD) also known as Hydroxymethylbilane synthase, is the third enzyme in the heme biosynthesis pathways in mammals<ref name="Raj">PMID: 19207107</ref>. It catalyses the polymerization of four porphobilinogen molecules to yield hydroxymethylbilane, a pyrrole<ref name="Peter">PMID:3079571</ref>. Porphobilinogen deaminases are able to form surprisingly stable enzyme-substrate complexes with up to four pyrrole substrates interacting with the active site, a feature unique to the group of enzymes<ref name="Anderson">PMID:7354069</ref>. Dipyrromethane, a cofactor unique to porphobilinogen deaminases, is thought to stabilize these interactions<ref name="Peter">PMID:3079571</ref>. | ||
=Function= | =Function= | ||
