Atropine: Difference between revisions
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=== Introduction and Background === | === Introduction and Background === | ||
[[Image:Atropine structure.jpg]] | [[Image:Atropine structure.jpg]]<ref> Image from: http://www.imctt-cw.org/pages/nerveagents.htm </ref> | ||
Atropine is an alkaloid drug derived from levohyscocyamine, a plant compound found in the family Solanaceae<ref> Atropine. Encyclopedia Brittanica. http://www.britannica.com/EBchecked/topic/42015/atropine</ref>. It's chemical name is 8-methyl-8-azabicycolo[3.2.1]oct-3-yl) 3-hydroxy-2-phenylpropanoate, and the most common medicinal form of atropine is atrophine sulfate ((C17H23NO3)2·H2SO4·H2O)<ref> Atropine. New World Encyclopedia. http://www.newworldencyclopedia.org/entry/Atropine </ref>. It is a competitive inhibitor of both acetylcholine and phospholipase 2 and has a variety of effects on both humans and animals. Although it is poisonous, in the correct dosages it has a wide variety of medical uses in both human and veterinary medicine, and can be given orally, through IV fluids, or rectally. Atropine can be seen in complex with phospholipase 2A on the right. The <scene name='Sandbox_53/side-chain residues/1'>side-chain residues</scene> of phospholipase A in the active site can be seen when zooming in on the protein to the right. | Atropine is an alkaloid drug derived from levohyscocyamine, a plant compound found in the family Solanaceae<ref> Atropine. Encyclopedia Brittanica. http://www.britannica.com/EBchecked/topic/42015/atropine</ref>. It's chemical name is 8-methyl-8-azabicycolo[3.2.1]oct-3-yl) 3-hydroxy-2-phenylpropanoate, and the most common medicinal form of atropine is atrophine sulfate ((C17H23NO3)2·H2SO4·H2O)<ref> Atropine. New World Encyclopedia. http://www.newworldencyclopedia.org/entry/Atropine </ref>. It is a competitive inhibitor of both acetylcholine and phospholipase 2 and has a variety of effects on both humans and animals. Although it is poisonous, in the correct dosages it has a wide variety of medical uses in both human and veterinary medicine, and can be given orally, through IV fluids, or rectally. Atropine can be seen in complex with phospholipase 2A on the right. The <scene name='Sandbox_53/side-chain residues/1'>side-chain residues</scene> of phospholipase A in the active site can be seen when zooming in on the protein to the right. | ||
