Sandbox 55: Difference between revisions
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Atorvastatin also is an agonist of aryl hydrocarbon receptor. Aryl hydrocarbon receptor is a ligand-activated transcriptional activator that binds to the promoter region of genes it activates. It specifically activates the expression of multiple phase I and II xenobiotic metabolizing enzyme genes (E.g. CYP3A4. Aryl hydrocarbon receptor also mediates the biochemical and toxic effects of halogenated aromatic hydrocarbons, cell-cycle regulation, and plays an important role in the development and maturation of tissues.<ref>LDL-C, Decreasing. "DrugBank: Atorvastatin (DB01076)." DrugBank: Welcome. Web. 09 Mar. 2011. <http://www.drugbank.ca/drugs/DB01076>.</ref> | Atorvastatin also is an agonist of aryl hydrocarbon receptor. Aryl hydrocarbon receptor is a ligand-activated transcriptional activator that binds to the promoter region of genes it activates. It specifically activates the expression of multiple phase I and II xenobiotic metabolizing enzyme genes (E.g. CYP3A4. Aryl hydrocarbon receptor also mediates the biochemical and toxic effects of halogenated aromatic hydrocarbons, cell-cycle regulation, and plays an important role in the development and maturation of tissues.<ref>LDL-C, Decreasing. "DrugBank: Atorvastatin (DB01076)." DrugBank: Welcome. Web. 09 Mar. 2011. <http://www.drugbank.ca/drugs/DB01076>.</ref> | ||
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