Simvastatin Synthase: Difference between revisions
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{{STRUCTURE_3hle | PDB=3hle | SCENE= }} | {{STRUCTURE_3hle | PDB=3hle | SCENE= }} | ||
==Introduction== | ==Introduction== | ||
Simvastation synthase (LovD) is an enzyme isolatied from the natural product biosynthetic pathways of''Aspergillus terreus''. | '''Simvastation synthase''' (LovD) is an enzyme isolatied from the natural product biosynthetic pathways of''Aspergillus terreus''. | ||
Simvastatin Synthase is an acyltransferase that converts the inactive monacolin J acid (MJA) | Simvastation synthase (LovD) is an enzyme isolatied from the natural product biosynthetic pathways ofAspergillus terreus. Simvastatin Synthase is an acyltransferase that converts the inactive monacolin J acid (MJA) by dimethylbutyryl chloride to yield the protected form of simvastatin, which is subsequently deprotected to yield simvastatin | ||
[[Image:LovD copy.jpg]] | |||
LovD can also synthesize the blockbuster drug simvastatin using MJA and a synthetic alpha-dimethylbutyryl thioester, albeit with suboptimal properties as a biocatalyst. | LovD can also synthesize the blockbuster drug simvastatin using MJA and a synthetic alpha-dimethylbutyryl thioester, albeit with suboptimal properties as a biocatalyst. | ||
Revision as of 00:20, 13 March 2011
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| 3hle, resolution 2.06Å (default scene) | |||||||||||||
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| Ligands: | DTT, MJA | ||||||||||||
| Related: | 1hld | ||||||||||||
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| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Introduction
Simvastation synthase (LovD) is an enzyme isolatied from the natural product biosynthetic pathways ofAspergillus terreus. Simvastation synthase (LovD) is an enzyme isolatied from the natural product biosynthetic pathways ofAspergillus terreus. Simvastatin Synthase is an acyltransferase that converts the inactive monacolin J acid (MJA) by dimethylbutyryl chloride to yield the protected form of simvastatin, which is subsequently deprotected to yield simvastatin File:LovD copy.jpg
LovD can also synthesize the blockbuster drug simvastatin using MJA and a synthetic alpha-dimethylbutyryl thioester, albeit with suboptimal properties as a biocatalyst.
Proteopedia Page Contributors and Editors (what is this?)
Eric Ginter, Michal Harel, Alexander Berchansky, David Canner
