2j20: Difference between revisions
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==About this Structure== | ==About this Structure== | ||
[[2j20]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J20 OCA]. | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:17015838</ref><references group="xtra"/> | <ref group="xtra">PMID:17015838</ref><ref group="xtra">PMID:14534297</ref><ref group="xtra">PMID:15703170</ref><references group="xtra"/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Ang, H C.]] | [[Category: Ang, H C.]] | ||
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[[Category: Glycoprotein]] | [[Category: Glycoprotein]] | ||
[[Category: Host-virus interaction]] | [[Category: Host-virus interaction]] | ||
[[Category: Li- fraumeni syndrome]] | |||
[[Category: Li-fraumeni syndrome]] | [[Category: Li-fraumeni syndrome]] | ||
[[Category: Metal-binding]] | [[Category: Metal-binding]] | ||
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[[Category: Tumor suppressor]] | [[Category: Tumor suppressor]] | ||
[[Category: Zinc]] | [[Category: Zinc]] | ||
Revision as of 19:24, 14 March 2011
HUMAN P53 CORE DOMAIN MUTANT M133L-V203A-N239Y-N268D-R273C
Template:ABSTRACT PUBMED 17015838
About this Structure
2j20 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Joerger AC, Ang HC, Fersht AR. Structural basis for understanding oncogenic p53 mutations and designing rescue drugs. Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15056-61. Epub 2006 Oct 2. PMID:17015838
- Joerger AC, Allen MD, Fersht AR. Crystal structure of a superstable mutant of human p53 core domain. Insights into the mechanism of rescuing oncogenic mutations. J Biol Chem. 2004 Jan 9;279(2):1291-6. Epub 2003 Oct 8. PMID:14534297 doi:10.1074/jbc.M309732200
- Joerger AC, Ang HC, Veprintsev DB, Blair CM, Fersht AR. Structures of p53 cancer mutants and mechanism of rescue by second-site suppressor mutations. J Biol Chem. 2005 Apr 22;280(16):16030-7. Epub 2005 Feb 9. PMID:15703170 doi:https://dx.doi.org/10.1074/jbc.M500179200
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Pages with broken file links
- Homo sapiens
- Ang, H C.
- Fersht, A R.
- Joerger, A C.
- Acetylation
- Activator
- Alternative splicing
- Anti-oncogene
- Apoptosis
- Cell cycle
- Disease mutation
- Dna-binding
- Dna-binding protein
- Glycoprotein
- Host-virus interaction
- Li- fraumeni syndrome
- Li-fraumeni syndrome
- Metal-binding
- Nuclear protein
- P53 dna-binding domain
- Phosphorylation
- Polymorphism
- Second-site suppressor mutation
- Superstable mutant
- Transcription
- Transcription regulation
- Transferase
- Tumor suppressor
- Zinc
