2bfb: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
m Protected "2bfb" [edit=sysop:move=sysop] |
(No difference)
| |
Revision as of 21:40, 14 March 2011
REACTIVITY MODULATION OF HUMAN BRANCHED-CHAIN ALPHA-KETOACID DEHYDROGENASE BY AN INTERNAL MOLECULAR SWITCH
Template:ABSTRACT PUBMED 16472748
About this Structure
2bfb is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Machius M, Wynn RM, Chuang JL, Li J, Kluger R, Yu D, Tomchick DR, Brautigam CA, Chuang DT. A versatile conformational switch regulates reactivity in human branched-chain alpha-ketoacid dehydrogenase. Structure. 2006 Feb;14(2):287-98. PMID:16472748 doi:10.1016/j.str.2005.10.009
- Li J, Wynn RM, Machius M, Chuang JL, Karthikeyan S, Tomchick DR, Chuang DT. Cross-talk between thiamin diphosphate binding and phosphorylation loop conformation in human branched-chain alpha-keto acid decarboxylase/dehydrogenase. J Biol Chem. 2004 Jul 30;279(31):32968-78. Epub 2004 May 27. PMID:15166214 doi:https://dx.doi.org/10.1074/jbc.M403611200
- Wynn RM, Machius M, Chuang JL, Li J, Tomchick DR, Chuang DT. Roles of His291-alpha and His146-beta' in the reductive acylation reaction catalyzed by human branched-chain alpha-ketoacid dehydrogenase: refined phosphorylation loop structure in the active site. J Biol Chem. 2003 Oct 31;278(44):43402-10. Epub 2003 Aug 5. PMID:12902323 doi:https://dx.doi.org/10.1074/jbc.M306204200
- Wynn RM, Ho R, Chuang JL, Chuang DT. Roles of active site and novel K+ ion-binding site residues in human mitochondrial branched-chain alpha-ketoacid decarboxylase/dehydrogenase. J Biol Chem. 2001 Feb 9;276(6):4168-74. Epub 2000 Nov 7. PMID:11069910 doi:10.1074/jbc.M008038200
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Pages with broken file links
- Homo sapiens
- Brautigam, C A.
- Chuang, D T.
- Chuang, J L.
- Machius, M.
- Tomchick, D R.
- Wynn, R M.
- Acylation
- Branched-chain
- Conformational switch
- Ketoacid dehydrogenase
- Maple syrup urine disease
- Multi- enzyme complex
- Oxidative decarboxylation
- Oxidoreductase
- Phosphorylation
- Reactivity
- Thiamine diphosphate