2hrm: Difference between revisions
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Revision as of 22:12, 14 March 2011
Crystal structure of dUTPase complexed with substrate analogue methylene-dUTP
Template:ABSTRACT PUBMED 17932923
About this Structure
2hrm is a 1 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
- Kovari J, Barabas O, Varga B, Bekesi A, Tolgyesi F, Fidy J, Nagy J, Vertessy BG. Methylene substitution at the alpha-beta bridging position within the phosphate chain of dUDP profoundly perturbs ligand accommodation into the dUTPase active site. Proteins. 2008 Apr;71(1):308-19. PMID:17932923 doi:10.1002/prot.21757
- Barabas O, Pongracz V, Kovari J, Wilmanns M, Vertessy BG. Structural insights into the catalytic mechanism of phosphate ester hydrolysis by dUTPase. J Biol Chem. 2004 Oct 8;279(41):42907-15. Epub 2004 Jun 17. PMID:15208312 doi:10.1074/jbc.M406135200
- Gonzalez A, Larsson G, Persson R, Cedergren-Zeppezauer E. Atomic resolution structure of Escherichia coli dUTPase determined ab initio. Acta Crystallogr D Biol Crystallogr. 2001 Jun;57(Pt 6):767-74. Epub 2001, May 25. PMID:11375495
