Sandbox Reserved 350: Difference between revisions
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The structure of Human Coagulation Factor V (FV) is sculpted from, originates from, precursors from a polypeptide to a A1-A2-B-A3-C1-C2 layout which results in the activated (FVa) protein. | The structure of Human Coagulation Factor V (FV) is sculpted from, originates from, precursors from a polypeptide to a A1-A2-B-A3-C1-C2 layout which results in the activated (FVa) protein. | ||
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'''-Heavy A1-A2 Chain''' | '''-Heavy A1-A2 Chain''' | ||
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'''-Light A3-C1-C2 Chain''' | '''-Light A3-C1-C2 Chain''' | ||
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FVa consists of a conserved '''β-Barrel framework''' acting as a scaffold for three loops and a '''C2 domain''' (FVa-C2). | |||
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'''The FVa-C2''', which is classified as a '''distorted jelly-roll β-barrel motif''', is compossed of e'''ight major antiparallel strands''' arranged into two '''β-sheets of five and three strands''' packed against one another. | |||
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The overall Barrel structure is closed at the top and bottom by '''three''' and '''two''' straight segments, giving it an '''overall spherical shape''' with a flattened upper surface. | |||
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Which once activated, enhances the ability of factor Xa to generate α-thrombin from prothrombin (5-Fold). | Which once activated, enhances the ability of factor Xa to generate α-thrombin from prothrombin (5-Fold). | ||
