Reserved Sandbox 329: Difference between revisions
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The bound [[ligand]] is an <scene name='Reserved_Sandbox_329/Ligand/4'>ATP complex</scene> with two Mg<sup>2+</sup> ions. | The bound [[ligand]] is an <scene name='Reserved_Sandbox_329/Ligand/4'>ATP complex</scene> with two Mg<sup>2+</sup> ions. | ||
[[Image:SECONDARY_STRUCTURE_SUCCESSION.jpg|thumb| | [[Image:SECONDARY_STRUCTURE_SUCCESSION.jpg|thumb|left|upright=2.0|alt=Secondary Structure Succession of ATP-bound TUTases|Secondary Structure Succession of ATP-bound TUTases.]] | ||
Revision as of 19:18, 16 March 2011
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| 2q0d, resolution 2.00Å (default scene) | |||||||||||||
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| Ligands: | ATP, MG | ||||||||||||
| Gene: | TUT4 (Trypanosoma brucei) | ||||||||||||
| Activity: | RNA uridylyltransferase, with EC number 2.7.7.52 | ||||||||||||
| Related: | 2ikf, 2nom | ||||||||||||
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| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Uridylyl transferases
INTRODUCTION
Terminal uridylyl transferases (TUTases) belong to a superfamily of polymerase ß nucleotidyl transferases.[1] TUTases have been isolated from Trypanosoma brucei and also Leishmania ssp, parasites causing diseases in humans such as African Sleeping Sickness.[2] Trypanosomal TUTases have RNA substrates that are shown to select for cognate nucleosides and provide a metal ion binding site for Mg2+ ions. TUTases function in RNA editing; they add UMP to the 3' hydroxyl group.[1]
STRUCTURE
The bound ligand is an ATP complex with two Mg2+ ions.
REFERENCES
- ↑ 1.0 1.1 Stagno J, Aphasizheva I, Aphasizhev R, Luecke H. Dual role of the RNA substrate in selectivity and catalysis by terminal uridylyl transferases. Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14634-9. Epub 2007 Sep 4. PMID:17785418
- ↑ Aphasizhev R, Sbicego S, Peris M, Jang SH, Aphasizheva I, Simpson AM, Rivlin A, Simpson L. Trypanosome mitochondrial 3' terminal uridylyl transferase (TUTase): the key enzyme in U-insertion/deletion RNA editing. Cell. 2002 Mar 8;108(5):637-48. PMID:11893335
