Lipase: Difference between revisions

From Proteopedia
Jump to navigationJump to search
No edit summary
Michal Harel (talk | contribs)
No edit summary
Line 23: Line 23:
[[1hlg]] – hLip – human - gastric<br />
[[1hlg]] – hLip – human - gastric<br />
[[3jw8]], [[3hju]] – mono-glyceride hLip<br />
[[3jw8]], [[3hju]] – mono-glyceride hLip<br />
[[1jmy]] – hLip – bile salt-stimulated (BAL) <br />
[[1jmy]] – hBSSL  <br />
[[1akn]] – BAL – ''Bos taurus''<br />
[[1akn]] – cBSSL – cattle <br />
[[1f6w]] - BAL – catalytic domain<br />
[[2bce]] - cBSSL (mutant) <br />
[[1gpl]] – Lip – guinea pig – RP2 (lipase related protein 2) <br />
[[1f6w]] - cBSSL – catalytic domain<br />
[[2bce]] – cBAL (mutant)<br />
[[3o0d]] – Lip – ''Yarrowia lipolytica''
[[3o0d]] – Lip – ''Yarrowia lipolytica''


Line 74: Line 73:
[[1eth]], [[1lpa]] - Lip+colipase II - pig<br />
[[1eth]], [[1lpa]] - Lip+colipase II - pig<br />


===Hormone-sensitive-lipases (HSL) hydrolyze the first fatty acid of the triacylglycerol substrate===
===Hormone-sensitive-lipases (LIPE) hydrolyze the first fatty acid of the triacylglycerol substrate===


[[3k6k]] – EstE7(HSL) – metagenome library<br />
[[3k6k]] – EstE7(LIPE) – metagenome library<br />
[[3fak]], [[3dnm]] – EstE5(HSL) – metagenome library<br />
[[3fak]], [[3dnm]] – EstE5(LIPE) – metagenome library<br />
[[1evq]] – AaEst2(HSL) – ''Alicyclobacillus acidocaldarius''<br />
[[1evq]] – AaEst2(LIPE) – ''Alicyclobacillus acidocaldarius''<br />
[[1u4n]] – AaEst2(HSL) (mutant) <br />
[[1u4n]] – AaEst2(LIPE) (mutant) <br />


===Putative lipases; Proteins with unknown function but structural similarity to lipase obtained in structural genomics projects. ===
===Putative lipases; Proteins with unknown function but structural similarity to lipase obtained in structural genomics projects. ===
Line 91: Line 90:
[[2pbl]] – Lip - ''Silicibacter''
[[2pbl]] – Lip - ''Silicibacter''


===Lipase inhibitors===
===Lipase + inhibitors===


[[3jwe]] - mono-glyceride hLip + SAR629 – covalent inhibitor<br />
[[3jwe]], [[3pe6]] - mono-glyceride hLip + SAR629 – covalent inhibitor<br />
[[3l1h]] – EstE5(HSL)+FeCl3  – noninvasive inhibitor<br />
[[3l1h]] – EstE5(LIPE)+FeCl3  – noninvasive inhibitor<br />
[[3l1i]], [[3l1j]] - EstE5(HSL)+CuSO4 – noninvasive inhibitor<br />
[[3l1i]], [[3l1j]] - EstE5(LIPE)+CuSO4 – noninvasive inhibitor<br />
[[3lij]] - EstE5(HSL)+ZnSO4– noninvasive inhibitor<br />
[[3lij]] - EstE5(LIPE)+ZnSO4– noninvasive inhibitor<br />
[[3h18]], [[3h17]] - EstE5 (HSL)+PMSF <br />
[[3h18]], [[3h17]] - EstE5 (LIPE)+PMSF <br />
[[3h19]], [[3h1b]], [[3h1a]] – EstE5 (HSL)+methyl alcohol<br />
[[3h19]], [[3h1b]], [[3h1a]] – EstE5 (LIPE)+methyl alcohol<br />
[[3h1a]] – EstE5 (HSL)+ethyl alcohol<br />
[[3h1a]] – EstE5 SLIPE)+ethyl alcohol<br />
[[3h19]] – EstE5 (HSL)+isopropyl alcohol<br />
[[3h19]] – EstE5 SLIPE)+isopropyl alcohol<br />
[[3g9t]], [[3g9u]] - EstE5 (HSL)+p-nitrophenyl butyrate<br />
[[3g9t]], [[3g9u]] - EstE5 (HSLIPE)+p-nitrophenyl butyrate<br />
[[3g9z]] - EstE5 (HSL) +p-nitrophenyl caprylate<br />
[[3g9z]] - EstE5 (LIPE) +p-nitrophenyl caprylate<br />
[[2nw6]] – BcLip+ S inhibitor <br />
[[2nw6]] – BcLip+ S inhibitor <br />
[[4lip]], [[5lip]], [[1r4z]], [[1r50]] – BcLip+ Rc-(Rp,Sp)-1,2-dioctylcarbamoyl-glycero-3-O-phosphonate<br />
[[4lip]], [[5lip]], [[1r4z]], [[1r50]] – BcLip+ Rc-(Rp,Sp)-1,2-dioctylcarbamoyl-glycero-3-O-phosphonate<br />
Line 118: Line 117:
[[1lpn]] – CrLip+ dodecanesulfonate <br />
[[1lpn]] – CrLip+ dodecanesulfonate <br />
[[1lpo]], [[1lpp]] – CrLip+ hexadecanesulfonate <br />
[[1lpo]], [[1lpp]] – CrLip+ hexadecanesulfonate <br />
[[1qz3]] – Est2(mutant) (HSL)+hexadecanesulfonate <br />
[[1qz3]] – EaEst2(mutant) (LIPE)+hexadecanesulfonate <br />


===Lipase showing bile-salt binding site===
===Lipase showing bile-salt binding site===


[[1aql]] – BAL+taurocholate <br />
[[1aql]] – cBSSL+taurocholate <br />


===Lipase with substrate bound at active site===
===Lipase with substrate bound at active site===