2p33: Difference between revisions
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New page: left|200px<br /> <applet load="2p33" size="450" color="white" frame="true" align="right" spinBox="true" caption="2p33, resolution 2.40Å" /> '''Synthesis and SAR o... |
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[[Image:2p33. | [[Image:2p33.jpg|left|200px]]<br /><applet load="2p33" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="2p33" size=" | |||
caption="2p33, resolution 2.40Å" /> | caption="2p33, resolution 2.40Å" /> | ||
'''Synthesis and SAR of Aminopyrimidines as Novel c-Jun N-Terminal Kinase (JNK) Inhibitors'''<br /> | '''Synthesis and SAR of Aminopyrimidines as Novel c-Jun N-Terminal Kinase (JNK) Inhibitors'''<br /> | ||
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==Overview== | ==Overview== | ||
The development of a series of novel aminopyrimidines as inhibitors of, c-Jun N-terminal kinases is described. The synthesis, in vitro inhibitory, values for JNK1, JNK2 and CDK2, and the in vitro inhibitory value for a, c-Jun cellular assay are discussed. | The development of a series of novel aminopyrimidines as inhibitors of, c-Jun N-terminal kinases is described. The synthesis, in vitro inhibitory, values for JNK1, JNK2 and CDK2, and the in vitro inhibitory value for a, c-Jun cellular assay are discussed. | ||
==About this Structure== | ==About this Structure== | ||
2P33 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with J07 as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] Full crystallographic information is available from [http:// | 2P33 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=J07:'>J07</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P33 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: jnk3 kinase]] | [[Category: jnk3 kinase]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 14:50:15 2008'' | ||
