Sandbox Reserved 316: Difference between revisions
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{{STRUCTURE_3hle | PDB=3hle | SCENE= }} | {{STRUCTURE_3hle | PDB=3hle | SCENE= }} | ||
==Introduction== | ==Introduction== | ||
'''Simvastation synthase''' (LovD) is an enzyme isolated from the natural product biosynthetic pathways of ''Aspergillus terreus''. Simvastatin Synthase is an acyltransferase that converts the inactive monacolin J acid (<scene name='Sandbox_Reserved_316/Blah/1'>MJA</scene>) by dimethylbutyryl chloride to yield the protected form of simvastatin, which is subsequently undergoes lactonization to yield simvastatin<ref name="paper">PMID:17277201</ref>. | '''Simvastation synthase''' (LovD) is an enzyme isolated from the natural product biosynthetic pathways of ''Aspergillus terreus''. Simvastatin Synthase is an acyltransferase that converts the inactive monacolin J acid (<scene name='Sandbox_Reserved_316/Blah/1'>MJA</scene>) by dimethylbutyryl chloride to yield the protected form of simvastatin, which is subsequently undergoes lactonization to yield simvastatin. LovD can also | ||
synthesize the blockbuster drug simvastatin using MJA and a synthetic α-dimethylbutyryl thioester. <ref name="paper">PMID:17277201</ref>. | |||
LovD can also synthesize the blockbuster drug simvastatin using MJA and a synthetic alpha-dimethylbutyryl thioester, albeit with suboptimal properties as a biocatalyst<ref name="paper">PMID:17277201</ref>. | LovD can also synthesize the blockbuster drug simvastatin using MJA and a synthetic alpha-dimethylbutyryl thioester, albeit with suboptimal properties as a biocatalyst<ref name="paper">PMID:17277201</ref>. | ||
