Sandbox Reserved 316: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Eric Ginter (talk | contribs) |
Eric Ginter (talk | contribs) No edit summary |
||
| Line 6: | Line 6: | ||
==Introduction== | ==Introduction== | ||
'''Simvastation synthase''' (LovD) is an enzyme isolated from the natural product biosynthetic pathways of ''Aspergillus terreus''. Simvastatin Synthase is an acyltransferase that converts the inactive monacolin J acid (<scene name='Sandbox_Reserved_316/Blah/1'>MJA</scene>) by dimethylbutyryl chloride to yield the protected form of simvastatin, which is subsequently undergoes lactonization to yield simvastatin. LovD can also | '''Simvastation synthase''' (LovD) is an enzyme isolated from the natural product biosynthetic pathways of ''Aspergillus terreus''. Simvastatin Synthase is an acyltransferase that converts the inactive monacolin J acid (<scene name='Sandbox_Reserved_316/Blah/1'>MJA</scene>) by dimethylbutyryl chloride to yield the protected form of simvastatin, which is subsequently undergoes lactonization to yield simvastatin. LovD can also | ||
synthesize the blockbuster drug simvastatin using MJA and a synthetic α-dimethylbutyryl thioester. <ref name=" | synthesize the blockbuster drug simvastatin using MJA and a synthetic α-dimethylbutyryl thioester. <ref name="paper1">PMID:17277201</ref>. | ||
LovD can also synthesize the blockbuster drug simvastatin using MJA and a synthetic alpha-dimethylbutyryl thioester, albeit with suboptimal properties as a biocatalyst<ref name=" | LovD can also synthesize the blockbuster drug simvastatin using MJA and a synthetic alpha-dimethylbutyryl thioester, albeit with suboptimal properties as a biocatalyst<ref name="paper1">PMID:17277201</ref>. | ||
==Exploring the structure== | ==Exploring the structure== | ||
LovD is a 413-amino acid protein predicted to have an α/β hydrolase fold based on primary sequence analysis<ref name="paper2">PMID:10334994</ref>. | |||
==References== | ==References== | ||
<references/> | <references/> | ||
10334994 | |||
