Sandbox Reserved 162: Difference between revisions

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== Structure ==

This structure of Interleukin-6 was crystallized at 1.9Å. IL-6 is a monomer of 185 amino acids coded by a gene found at locus 7p21 which codes for four introns and five exons. It contains <scene name='Sandbox_Reserved_162/5_helices/2'>five alpha helices</scene>, four of which constitute a classical four-helix bundle with the fifth helix located in the C-D loop. The four helices that form the four-helix bundle are arranged so that two helices (A & B) run parrallel and two (C & D) in an opposing direction. The N-terminal 18 amino acids of IL-6 are not visible in electron density maps and consequently have not been modeled. The first long helix <scene name='Sandbox_Reserved_162/Helix_a/1'>(A)</scene> extends from Ser21 to Ala45 and is connected to a parallel helix (B) by a 25 amino acid loop. This helix <scene name='Sandbox_Reserved_162/Helix_b/2'>(B)</scene> extends from Glu80 to Gln102. A short connection formed from Asn103 to Ser108 joins this helix to the next helix (C). This third helix extends from Glu109 to Lys129 and is followed by another amino acid loop which includes a short helix of three turns (Pro141-Gln152). The last helix (D) extends from Gln156 to Arg182 (Citation).

This structure of Interleukin-6 was crystallized at 1.9Å. IL-6 is a monomer of 185 amino acids coded by a gene found at locus 7p21 which codes for four introns and five exons. It contains <scene name='Sandbox_Reserved_162/5_helices/2'>five alpha helices</scene>, four of which constitute a classical four-helix bundle with the fifth helix located in the C-D loop. The four helices that form the four-helix bundle are arranged so that two helices (A & B) run parrallel and two (C & D) in an opposing direction. The N-terminal 18 amino acids of IL-6 are not visible in electron density maps and consequently have not been modeled. The first long helix <scene name='Sandbox_Reserved_162/Helix_a/1'>(A)</scene> extends from Ser21 to Ala45 and is connected to a parallel helix (B) by a 25 amino acid loop. This helix <scene name='Sandbox_Reserved_162/Helix_b/2'>(B)</scene> extends from Glu80 to Gln102. A short connection formed from Asn103 to Ser108 joins this helix to the next helix <scene name='Sandbox_Reserved_162/Helix_c/1'>(C)</scene>. This third helix extends from Glu109 to Lys129 and is followed by another amino acid loop which includes a short helix of three turns (Pro141-Gln152). The last helix (D) extends from Gln156 to Arg182 (Citation).

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 == Structure ==
-This structure of Interleukin-6 was crystallized at 1.9Å. IL-6 is a monomer of 185 amino acids coded by a gene found at locus 7p21 which codes for four introns and five exons. It contains <scene name='Sandbox_Reserved_162/5_helices/2'>five alpha helices</scene>, four of which constitute a classical four-helix bundle with the fifth helix located in the C-D loop. The four helices that form the four-helix bundle are arranged so that two helices (A & B) run parrallel and two (C & D) in an opposing direction. The N-terminal 18 amino acids of IL-6 are not visible in electron density maps and consequently have not been modeled. The first long helix <scene name='Sandbox_Reserved_162/Helix_a/1'>(A)</scene> extends from Ser21 to Ala45 and is connected to a parallel helix (B) by a 25 amino acid loop. This helix <scene name='Sandbox_Reserved_162/Helix_b/2'>(B)</scene> extends from Glu80 to Gln102. A short connection formed from Asn103 to Ser108 joins this helix to the next helix (C). This third helix extends from Glu109 to Lys129 and is followed by another amino acid loop which includes a short helix of three turns (Pro141-Gln152). The last helix (D) extends from Gln156 to Arg182 (Citation).
+This structure of Interleukin-6 was crystallized at 1.9Å. IL-6 is a monomer of 185 amino acids coded by a gene found at locus 7p21 which codes for four introns and five exons. It contains <scene name='Sandbox_Reserved_162/5_helices/2'>five alpha helices</scene>, four of which constitute a classical four-helix bundle with the fifth helix located in the C-D loop. The four helices that form the four-helix bundle are arranged so that two helices (A & B) run parrallel and two (C & D) in an opposing direction. The N-terminal 18 amino acids of IL-6 are not visible in electron density maps and consequently have not been modeled. The first long helix <scene name='Sandbox_Reserved_162/Helix_a/1'>(A)</scene> extends from Ser21 to Ala45 and is connected to a parallel helix (B) by a 25 amino acid loop. This helix <scene name='Sandbox_Reserved_162/Helix_b/2'>(B)</scene> extends from Glu80 to Gln102. A short connection formed from Asn103 to Ser108 joins this helix to the next helix <scene name='Sandbox_Reserved_162/Helix_c/1'>(C)</scene>. This third helix extends from Glu109 to Lys129 and is followed by another amino acid loop which includes a short helix of three turns (Pro141-Gln152). The last helix (D) extends from Gln156 to Arg182 (Citation).
 == Functions ==