Prion: Difference between revisions

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New page: left|200px|thumb|Crystal Structure of human prion [[3haf]] {{STRUCTURE_3haf| PDB=3haf | SIZE=300| SCENE= |right|CAPTION=human prion 3haf }} '''Prion''' (PrP) is ...
 
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[[Image:3haf.png|left|200px|thumb|Crystal Structure of human prion [[3haf]]]]
[[Image:3haf.png|left|200px|thumb|Crystal Structure of human prion [[3haf]]]]
{{STRUCTURE_3haf|  PDB=3haf  | SIZE=300| SCENE= |right|CAPTION=human prion [[3haf]] }}
{{STRUCTURE_3haf|  PDB=3haf  | SIZE=300| SCENE= |right|CAPTION=human prion [[3haf]] }}


'''Prion''' (PrP) is a protein which becomes infectious upon undergoing conformation change to an amyloid form, which is self-propagating and become resistant to protease degradation.  The fungus Podospora anserine has a prion-like protein HET-S which undergoes a conformation change to amyloid form which prevents its colony from merging with non-compatible colonies.  Yeast prion proteins are Sup35 and Ure2.  The images at the left and at the right correspond to one representative prion, ''i.e.'' the crystal structure of human prion ([[2haf]]).
'''Prion''' (PrP) is a protein which becomes infectious upon undergoing conformation change to an amyloid form, which is self-propagating and becomes resistant to protease degradation.  The fungus ''Podospora anserine'' has a prion-like protein HET-S which undergoes a conformation change to amyloid form which prevents its colony from merging with non-compatible colonies.  Yeast prion proteins are Sup35 and Ure2.  The images at the left and at the right correspond to one representative prion, ''i.e.'' the crystal structure of human prion ([[2haf]]).


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===PrP short polypeptides===
[[3nve]] – ShPrP residues 138 -143 – Syrian hamster<br />
[[2kkg]] - PrP residues 23 -106 – Golden hamster - NMR<br />
[[3nvf]] – hPrP residues 138 -143 – human<br />
[[2ol9]] - hPrP residues 170 – 175<br />
[[3nhc]], [[3nhd]] - hPrP residues 127 – 132<br />
[[2iv5]] - hPrP residues 173 -195 – NMR<br />
[[1oei]] - hPrP residues 61 - 84 – NMR<br />
[[1oeh]] - hPrP residues 61 - 68 – NMR<br />
[[2iv6]] - hPrP residues 173 -195 (mutant) – NMR<br />
[[2iv4]] - hPrP residues 180 -195 – NMR<br />
[[3nvg]], [[3nvh]] - mPrP residues 138 -143 – mouse<br />
[[1skh]] - bPrP residues 1 – 30 - bovine<br />
[[3fva]] - ePrP residues 173 -178 – Elk<br />
[[1s4t]] - sPrP residues 135 – 155 – sheep – NMR<br />
[[1m25]] - sPrP residues 152 – 156 – NMR<br />
[[1g04]] - sPrP residues 145 – 169 – NMR<br />
[[2rmv]], [[2rmw]] - sPrP residues 142 – 166 (mutant) – NMR
===PrP===
[[3o79]] – rPrP C-terminal – rabbit<br />
[[2fj3]] - rPrP C-terminal – NMR<br />
[[2joh]], [[2jom]] - rPrP C-terminal (mutant) – NMR<br />
[[2ku4]] - PrP C-terminal – horse<br />
[[3fva]] - ePrP C-terminal – NMR<br />
[[2kfl]] - PrP C-terminal – Wallaby – NMR<br />
[[2k56]] - PrP C-terminal – Vole – NMR<br />
[[2ktm]] – sPrP residues 167-234 H2H3 domain (mutant) – NMR<br />
[[1xyu]], [[1y2s]] - sPrP C-terminal – NMR<br />
[[1uw3]] - sPrP C-terminal<br />
[[3haf]], [[3hak]], [[3hj5]], [[1i4m]] - hPrP C-terminal<br />
[[1hjm]], [[1hjn]], [[2kun]] – hPrP C-terminal – NMR<br />
[[1h0l]], [[1fkc]], [[2k1d]], [[1fo7]], [[1e1s]], [[1e1g]], [[1e1j]], [[1e1p]], [[1e1u]], [[1e1w]], [[1qlx]], [[1qlz]], [[1qm0]], [[1qm1]], [[1qm2]], [[1qm3]] - hPrP C-terminal (mutant) - NMR<br />
[[2ku5]], [[2ku6]], [[2kfm]], [[2kfo]], [[2k5o]], [[1y16]], [[1y15]] - mPrP C-terminal  (mutant)<br />
[[1xyx]] - mPrP C-terminal<br />
[[1u3m]] – PrP C-terminal – chicken – NMR<br />
[[1u5l]] - PrP C-terminal – turtle – NMR<br />
[[1xu0]] - PrP C-terminal – frog – NMR<br />
[[1xyj]] - PrP C-terminal – cat – NMR<br />
[[1xyk]] - PrP C-terminal  – dog – NMR<br />
[[1xyq]] - PrP C-terminal – pig – NMR<br />
[[1dwy]], [[1dx0]], [[1dx1]] - bPrP C-terminal – NMR<br />
[[1b10]] - ShPrP C-terminal – NMR
===Yeast prions===
[[2onx]], [[2olx]] – Sup35 residues 8 - 11 – yeast<br />
[[2omm]], [[1yjo]], [[1yjp]] – Sup35 residues 7 – 13<br />
[[1jzr]], [[1k0a]], [[1k0b]], [[1k0c]], [[1k0d]] – Ure2p + glutathione derivartive<br />
[[1g6w]], [[1g6y]] – Ure2p globular domain<br />
[[1hqo]] – Ure2p nitrogen regulation fragment
===PrP+antibody===
[[2w9e]] - hPrP C-terminal + anti-PrP antibody<br />
[[2hh0]] - bPrP peptide epitope + anti-PrP antibody<br />
[[1cu4]] - ShPrP peptide epitope + anti-PrP antibody<br />
[[1tpx]], [[1tqb]], [[1tqc]] - sPrP C-terminal + anti-PrP antibody
===HET-S from ''Podospora anserine''===
[[2kj3]], [[2rnm]] – HET-S C-terminal – NMR<br />
[[2wvn]], [[2wvo]] - HET-S N-terminal<br />
[[2wvq]] - HET-S N-terminal (mutant)
[[Category:Topic Page]]
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