Sandbox Reserved 196: Difference between revisions

From Proteopedia
Jump to navigationJump to search
No edit summary
No edit summary
Line 6: Line 6:
== Introduction ==
== Introduction ==


RNase B is a glycoprotein that can that cleave N-linked carbohydrates (1). RNase B is structurally the same as RNase A. However is has an additional catalytic activity caused by the attachment of polysaccharrides at the Asn-34. This small change allows RNase B to hydrolyze double-stranded RNA at ionic strengths where RNase A has no activity.  This shows that small changes in the active sites of very similar molecules can lead to todally new roles and activities. (2)
RNase B is a glycoprotein that can that cleave N-linked carbohydrates <ref>New England Bio Lab, INC http://www.neb.com/nebecomm/products/productP7817.asp</ref>. RNase B is structurally the same as RNase A. However is has an additional catalytic activity caused by the attachment of polysaccharrides at the Asn-34. This small change allows RNase B to hydrolyze double-stranded RNA at ionic strengths where RNase A has no activity.  This shows that small changes in the active sites of very similar molecules can lead to todally new roles and activities. <ref>PMID:3680242</ref>
== Background ==
== Background ==
[[Image:RNaseB.png | thumb|left|RNase B]]
[[Image:RNaseB.png | thumb|left|RNase B]]
Line 22: Line 22:


== References ==
== References ==
<ref group=>New England Bio Lab, INC http://www.neb.com/nebecomm/products/productP7817.asp</ref><references />
<ref group=>PMID:3680242</ref><references />


== Additional Resources ==
== Additional Resources ==
<ref group="xtra">Dr. Johnson</ref>
<ref group="xtra">Dr. Johnson</ref>
<references group="xtra"/>
<references group="xtra"/>