Sandbox Reserved 168: Difference between revisions
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SKI, as mentioned before is an oncoprotein that represses TGF-beta and nuclear receptor signaling. It is involved in the regulation of cellular transformation and differentiation. The SKI protein has been associated with tumors at large levels of cellular concentrations and it has been shown to interfere with normal cellular functioning. It was recently discovred that SKI plays a role not only inside the nucleus but also outside of the nucleus in the cytoplasm. | SKI, as mentioned before is an oncoprotein that represses TGF-beta and nuclear receptor signaling. It is involved in the regulation of cellular transformation and differentiation. The SKI protein has been associated with tumors at large levels of cellular concentrations and it has been shown to interfere with normal cellular functioning. It was recently discovred that SKI plays a role not only inside the nucleus but also outside of the nucleus in the cytoplasm. | ||
== Clinical Applications == | |||
SKI has been linked to various types of cancer such as melanoma, esophageal cell carcinoma, cervical cancer and the process of tumor progresssion. The SKI oncoprotein has been demonstrated to assist tyrosine kinases to cause leukemia, recently it has been demonstrated that the protein also plays a regulatory role in several signal transduction pathways that are frequent targets for mutagenesis in human tumors. | |||
== References == | == References == | ||
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