Prp24: Difference between revisions
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The U4 snRNA is though to be non-catalytic because it leaves the spliceosome before the transesterification reactions occur <ref name="Staley"/>. Its function is instead thought to be aiding U6 in maintaining a conformation that will enable it to interact with U2 and the 5' splice site. The U4 snRNP contains the U4 snRNA, a ring complex of the Sm proteins B-G, and the proteins Prp3, Prp4, and Snu13 <ref name="Brow review"/>. | The U4 snRNA is though to be non-catalytic because it leaves the spliceosome before the transesterification reactions occur <ref name="Staley"/>. Its function is instead thought to be aiding U6 in maintaining a conformation that will enable it to interact with U2 and the 5' splice site. The U4 snRNP contains the U4 snRNA, a ring complex of the Sm proteins B-G, and the proteins Prp3, Prp4, and Snu13 <ref name="Brow review"/>. | ||
The annealing of the U4 and U6 snRNAs to form the U4/U6 di-snRNP complex, which contains the additional proteins Prp6 and Prp31, is an essential process in the formation of the spliceosome <ref name="Brow review"/>. It enables interaction with the U5 snRNP to form the U4/U6.U5 complex which serves to deliver the U5 and U6 snRNPs to the appropriate sites in the pre-spliceosome complex to form a catalytically active spliceosome upon departure of U1 and U4 <ref name="Brow/>. | The annealing of the U4 and U6 snRNAs to form the U4/U6 di-snRNP complex, which contains the additional proteins Prp6 and Prp31, is an essential process in the formation of the spliceosome <ref name="Brow review"/>. It enables interaction with the U5 snRNP to form the U4/U6.U5 complex which serves to deliver the U5 and U6 snRNPs to the appropriate sites in the pre-spliceosome complex to form a catalytically active spliceosome upon departure of U1 and U4 <ref name="Brow"/>. | ||
===Role of Prp24 in Splicing=== | ===Role of Prp24 in Splicing=== | ||
