Sandbox Reserved 200: Difference between revisions
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=Introduction= | =Introduction= | ||
[[Image:2D_RNase_A.png|200px|left|thumb|RNase A minor dimer,[[1A2W]]]] | [[Image:2D_RNase_A.png|200px|left|thumb|RNase A minor dimer,[[1A2W]]]] | ||
Bovine pancreatic ribonuclease A | Bovine pancreatic ribonuclease A [http://en.wikipedia.org/wiki/Ribonuclease_A (RNase A)] is an enzyme that catalyzes the hydrolysis of RNA through [http://www.proteopedia.org/wiki/index.php/Sandbox_Reserved_193 acid-base catalysis]. RNase A has the capability to structurally form dimers, trimers, and other oligomers based on the structure of the [http://www.proteopedia.org/wiki/index.php/Sandbox_Reserved_192 Structure of RNase A monomer]. The oligomers are formed by 3D domain swapping, which can occur once or twice per monomeric unit <ref name="liul">PMID:11224563</ref >. The 3D domain swapping has no impact on the formation of active sites. These same active sites, which are composed of His 12, Lys 41, and His 119, can be found in the monomer, dimer, and trimer <ref name="liul"/>. | ||
<Structure load='1A2W' size='400' frame='true' align='right' caption='Ribonuclease A Dimer' scene='Sandbox_Reserved_200/Minor_dimer/2' /> | <Structure load='1A2W' size='400' frame='true' align='right' caption='Ribonuclease A Dimer' scene='Sandbox_Reserved_200/Minor_dimer/2' /> | ||
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=External Links= | =External Links= | ||
[http://en.wikipedia.org/wiki/Ribonuclease_A Wikipedia Ribonuclease A] | [http://en.wikipedia.org/wiki/Ribonuclease_A Wikipedia Ribonuclease A] | ||
[http://www.proteopedia.org/wiki/index.php/Sandbox_Reserved_192 Structure of RNase A monomer] | |||
[http://www.proteopedia.org/wiki/index.php/Sandbox_Reserved_193 Acid-base catalysis of RNase A] | |||
