Prp19: Difference between revisions
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PRP19 (precusor RNA processing 19) is a splicing factor which is essential for proper pre-mRNA processing.<ref>PMID:10092627</ref>Its presence is required prior to the first splicing step, in which the 5' splice site is cleaved and a lariat intron/3' exon intermediate is formed. Through various isolation methods, over 40 PRP genes have been identified<ref name = "functional">PMID:8194532</ref> - many of which have very similar homology and motifs such as [http://en.wikipedia.org/wiki/Zinc_fingers <i>Zinc fingers</i>], RNA binding motifs, ATP dependent helicase and a motif for the beta subunit of G protein.<ref name="novel">PMID:8441419</ref>. However, PRP19 had no homological similarities to any known sequences. The function of PRP proteins can be broken down into three main categories, those involved in the first chemical step, such as PRP19, those involved in the accumulation of splicing intermediates, and those involved in the formation of the lariat-intron product. | PRP19 (precusor RNA processing 19) is a splicing factor which is essential for proper pre-mRNA processing.<ref>PMID:10092627</ref>Its presence is required prior to the first splicing step, in which the 5' splice site is cleaved and a lariat intron/3' exon intermediate is formed. Through various isolation methods, over 40 PRP genes have been identified<ref name = "functional">PMID:8194532</ref> - many of which have very similar homology and motifs such as [http://en.wikipedia.org/wiki/Zinc_fingers <i>Zinc fingers</i>], RNA binding motifs, ATP dependent helicase and a motif for the beta subunit of G protein.<ref name="novel">PMID:8441419</ref>. However, PRP19 had no homological similarities to any known sequences. The function of PRP proteins can be broken down into three main categories, those involved in the first chemical step, such as PRP19, those involved in the accumulation of splicing intermediates, and those involved in the formation of the lariat-intron product. | ||
<ref name="novel"/> | <ref name="novel"/> | ||
==Structure== | |||
==Role in Splicing== | ==Role in Splicing== | ||
