Sandbox Reserved 309: Difference between revisions
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With no ligand, is represented by a central CORE domain composed of a 5-stranded parallel beta sheet surrounded by 7 alpha helices, and two periferal domains, LID and NMP <ref name=Miron>PMID:14705932 </ref>, these two binding regions participate in the isolation of the substrates during catalysis and usually undergo significant conformational changes during the reaction <ref name=Bellinzoni>PMID: 16672241 </ref> | With no ligand, is represented by a central CORE domain composed of a 5-stranded parallel beta sheet surrounded by 7 alpha helices, and two periferal domains, LID and NMP <ref name=Miron>PMID:14705932 </ref>, these two binding regions participate in the isolation of the substrates during catalysis and usually undergo significant conformational changes during the reaction <ref name=Bellinzoni>PMID: 16672241 </ref> | ||
==The crystalline structure== | ==The crystalline structure== | ||
Globular with a central core made by a <scene name='Sandbox_Reserved_309/Beta_parallel_sheet/1'>beta parallel sheet</scene> surrounded by alpha helices, a P-loop motif at the N-terminus that binds ATP, and two regions (LID and NMP). <ref name=Bellinzoni>PMID: 16672241 </ref> | Globular with a central core made by a <scene name='Sandbox_Reserved_309/Beta_parallel_sheet/1'>beta parallel sheet</scene> surrounded by alpha helices, a P-loop motif at the N-terminus that binds ATP, and two regions (LID and NMP).The LID region consists of a ten residue loop and is depicted in grey and green in the above image. <ref name=Bellinzoni>PMID: 16672241 </ref> | ||
=Function= | =Function= | ||
*Involved in nucleotide biosynthesis, which is very important as the intervention point for therapeutic agents. | *Involved in nucleotide biosynthesis, which is very important as the intervention point for therapeutic agents. | ||
