Sandbox Reserved 309: Difference between revisions
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=Introduction/General Information= | =Introduction/General Information= | ||
Adenylate kinase is a phosphotransferase that catalyzes the interconversion reaction of ATP, ADP, and AMP. Phosphotransferases include enzymes that catalyze phosphorylation reactions like the mechanism depicted below. It is part of the nucleotide and nucleoside kinases family. The adenylate kinase family can be classified into two groups: a long variant group, possessing a longer LID domain, and a short variant group where the ''Myobacterium tuberculosis'' bacterium can be found <ref name=Bellinzoni>PMID: 16672241 </ref>. Since the source of this form of adenylate kinase is ''M. tuberculosis'' it is very important in developing treatment for tuberculosis in humans, as it is found to be essential for bacterial survival, and is therefore an excellent target for drugs when treating the disease. <ref name=Bellinzoni>PMID: 16672241 </ref> Since tuberculosis is the leading cause of death from infectious disease worldwide, adenylate kinase is therefore a crucial protein in finding therapeutic tools required for prevention and treatment of this common and deadly disease. | Adenylate kinase is a phosphotransferase that catalyzes the interconversion reaction of ATP, ADP, and AMP. Phosphotransferases include enzymes that catalyze phosphorylation reactions like the mechanism depicted below. It is part of the nucleotide and nucleoside kinases family. The adenylate kinase family can be classified into two groups: a long variant group, possessing a longer LID domain, and a short variant group where the ''Myobacterium tuberculosis'' bacterium can be found <ref name=Bellinzoni>PMID: 16672241 </ref>. Since the source of this form of adenylate kinase is ''M. tuberculosis'' it is very important in developing treatment for tuberculosis in humans, as it is found to be essential for bacterial survival, and is therefore an excellent target for drugs when treating the disease. <ref name=Bellinzoni>PMID: 16672241 </ref> Since tuberculosis is the leading cause of death from infectious disease worldwide, adenylate kinase is therefore a crucial protein in finding therapeutic tools required for prevention and treatment of this common and deadly disease. <ref name=Miron>PMID:14705932 </ref> | ||
=Structure= | =Structure= | ||
[[Image:LID_and_NMP_region.png]] | [[Image:LID_and_NMP_region.png]] | ||
