Prp19: Difference between revisions
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=Structure= | =Structure= | ||
In Humans, the gene which is homologous to that of PRP19 in ''S. cerevisiae'' is located on chromosome 11 (11q12.2).<ref>"Entrez Gene: PRPF19 PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27339.</ref> The protein is 503 amino acid residues in length and forms a tetramer with a centrally coiled domain<Ref name="something">PMID:16388587</ref>. The protein was found to have a molecular weight of 56 kDa <ref>pmid:17276391</ref>Two majors functional domains have been identified, the [http://proteopedia.com/wiki/index.php/3lrv <i>WD40 domain</i>] and the [http://proteopedia.com/wiki/index.php/2bay <i>U Box domain</i>]<ref="wd40domain">pmid:20462492</ref> | In Humans, the gene which is homologous to that of PRP19 in ''S. cerevisiae'' is located on chromosome 11 (11q12.2).<ref>"Entrez Gene: PRPF19 PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27339.</ref> The protein is 503 amino acid residues in length and forms a tetramer with a centrally coiled domain<Ref name="something">PMID:16388587</ref>. The protein was found to have a molecular weight of 56 kDa <ref>pmid:17276391</ref>Two majors functional domains have been identified, the [http://proteopedia.com/wiki/index.php/3lrv <i>WD40 domain</i>] and the [http://proteopedia.com/wiki/index.php/2bay <i>U Box domain</i>]<ref name="wd40domain">pmid:20462492</ref> | ||
