Prp19: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Aaron Smith (talk | contribs) |
Aaron Smith (talk | contribs) |
||
| Line 25: | Line 25: | ||
[[Image:3LRV_-_secondary_small.jpg]] Secondary Structure of the WD40 Domain of PRP19. Beta Propeller structures can be seen. | [[Image:3LRV_-_secondary_small.jpg]] Secondary Structure of the WD40 Domain of PRP19. Beta Propeller structures can be seen. | ||
WD40 domains can be found throughout a large variety of organisms and are highly abundant in eukaryotic proteins. WD40 domains can have several functions including cell cycle control, involvement in signal transduction, assembly of the cytoskeleton, gene transcriptional activiation and pre mRNA processing. Conserved repeats ~40 residues long, consisting of tryptophan and aspartic acid residues, form Beta Propeller structures which can be seen in the image to the left as well as in the default scene image. The default scene also shows 4 SO4 molecules binding which help to activate the complex. Beta Propeller repeats can often as as platforms for binding of other proteins or ligands. <ref>http://pawsonlab.mshri.on.ca/index.php?option=com_content&task=view&Itemid=64&id=190</ref> The WD40 domain of PRP19 is found between residues 165 and 503. Its structure was solved in 2010 by X-Ray diffraction at a resolution of 2.6 Angstroms.<ref name=" | WD40 domains can be found throughout a large variety of organisms and are highly abundant in eukaryotic proteins. WD40 domains can have several functions including cell cycle control, involvement in signal transduction, assembly of the cytoskeleton, gene transcriptional activiation and pre mRNA processing. Conserved repeats ~40 residues long, consisting of tryptophan and aspartic acid residues, form Beta Propeller structures which can be seen in the image to the left as well as in the default scene image. The default scene also shows 4 SO4 molecules binding which help to activate the complex. Beta Propeller repeats can often as as platforms for binding of other proteins or ligands. <ref>http://pawsonlab.mshri.on.ca/index.php?option=com_content&task=view&Itemid=64&id=190</ref> The WD40 domain of PRP19 is found between residues 165 and 503. Its structure was solved in 2010 by X-Ray diffraction at a resolution of 2.6 Angstroms.<ref name="wd40domain"/> | ||
=Role in Splicing= | =Role in Splicing= | ||
