Prp19: Difference between revisions
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=The Nineteen Complex= | =The Nineteen Complex= | ||
The NTC consists of at least 8 protein components and is associated with the spliceosome as U4 dissociates or immediately there after. | The NTC consists of at least 8 protein components and is associated with the spliceosome as U4 dissociates or immediately there after.<ref>pmid:16540691</ref> | ||
Research has shown that PRP19 is required for a reaction in which the structure of the U6 snRNP is re-arranged involving destabilization of [http://en.wikipedia.org/wiki/LSm<i>Lsm</i>] proteins. This destabilization is thought to help facilitate interaction between the intron closest to the 5’ splice site and the Lsm binding site of U6. | Research has shown that PRP19 is required for a reaction in which the structure of the U6 snRNP is re-arranged involving destabilization of [http://en.wikipedia.org/wiki/LSm<i>Lsm</i>] proteins. This destabilization is thought to help facilitate interaction between the intron closest to the 5’ splice site and the Lsm binding site of U6. | ||
