Prp19: Difference between revisions

Line 23:

[[Image:3LRV_-_secondary_small.jpg]] Secondary Structure of the WD40 Domain of PRP19. The Beta Propeller fold can be seen.

WD40 domains can be found throughout a large variety of organisms and are highly abundant in eukaryotic proteins. WD40 domains can have several functions including cell cycle control, involvement in signal transduction, assembly of the cytoskeleton, gene transcriptional activiation and pre mRNA processing. Conserved repeats ~40 residues long, consisting of tryptophan and aspartic acid residues, form a Beta Propeller fold which can be seen in the image to the left as well as in the default scene image. The default scene also shows 4 SO4 molecules binding which help to activate the complex. Blade repeats can often be used as platforms for binding of other proteins or ligands.<ref>http://pawsonlab.mshri.on.ca/index.php?option=com_content&task=view&Itemid=64&id=190</ref><ref>pmid:10322433</ref>. The propeller fold in PRP19's WD40 domain is comprised of seven blades and is asymmetrical due to a slight distortion in blades one and seven. The region around blade five is highly conserved and is necessary for interaction between PRP19 and Cwc2, another splicing factor found in the NTC. The WD40 domain of PRP19 is found between residues 165 and 503. Its structure was solved in 2010 by X-Ray diffraction at a resolution of 2.6 Angstroms.<ref name="wd40domain"/>

WD40 domains can be found throughout a large variety of organisms and are highly abundant in eukaryotic proteins<ref>pmid:11814058.</ref>. WD40 domains can have several functions including cell cycle control, involvement in signal transduction, assembly of the cytoskeleton, gene transcriptional activiation and pre mRNA processing. Conserved repeats ~40 residues long, consisting of tryptophan and aspartic acid residues, form a Beta Propeller fold which can be seen in the image to the left as well as in the default scene image. The default scene also shows 4 SO4 molecules binding which help to activate the complex. Blade repeats can often be used as platforms for binding of other proteins or ligands.<ref>http://pawsonlab.mshri.on.ca/index.php?option=com_content&task=view&Itemid=64&id=190</ref><ref>pmid:10322433</ref>. The propeller fold in PRP19's WD40 domain is comprised of seven blades and is asymmetrical due to a slight distortion in blades one and seven. The region around blade five is highly conserved and is necessary for interaction between PRP19 and Cwc2, another splicing factor found in the NTC. The WD40 domain of PRP19 is found between residues 165 and 503. Its structure was solved in 2010 by X-Ray diffraction at a resolution of 2.6 Angstroms.<ref name="wd40domain"/>

=Role in Splicing=

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 23: / Line 23: @@
 [[Image:3LRV_-_secondary_small.jpg]] Secondary Structure of the WD40 Domain of PRP19. The Beta Propeller fold can be seen.
-WD40 domains can be found throughout a large variety of organisms and are highly abundant in eukaryotic proteins. WD40 domains can have several functions including cell cycle control, involvement in signal transduction, assembly of the cytoskeleton, gene transcriptional activiation and pre mRNA processing. Conserved repeats ~40 residues long, consisting of tryptophan and aspartic acid residues, form a Beta Propeller fold which can be seen in the image to the left as well as in the default scene image. The default scene also shows 4 SO4 molecules binding which help to activate the complex. Blade repeats can often be used as platforms for binding of other proteins or ligands.<ref>http://pawsonlab.mshri.on.ca/index.php?option=com_content&task=view&Itemid=64&id=190</ref><ref>pmid:10322433</ref>. The propeller fold in PRP19's WD40 domain is comprised of seven blades and is asymmetrical due to a slight distortion in blades one and seven. The region around blade five is highly conserved and is necessary for interaction between PRP19 and Cwc2, another splicing factor found in the NTC. The WD40 domain of PRP19 is found between residues 165 and 503. Its structure was solved in 2010 by X-Ray diffraction at a resolution of 2.6 Angstroms.<ref name="wd40domain"/>
+WD40 domains can be found throughout a large variety of organisms and are highly abundant in eukaryotic proteins<ref>pmid:11814058.</ref>. WD40 domains can have several functions including cell cycle control, involvement in signal transduction, assembly of the cytoskeleton, gene transcriptional activiation and pre mRNA processing. Conserved repeats ~40 residues long, consisting of tryptophan and aspartic acid residues, form a Beta Propeller fold which can be seen in the image to the left as well as in the default scene image. The default scene also shows 4 SO4 molecules binding which help to activate the complex. Blade repeats can often be used as platforms for binding of other proteins or ligands.<ref>http://pawsonlab.mshri.on.ca/index.php?option=com_content&task=view&Itemid=64&id=190</ref><ref>pmid:10322433</ref>. The propeller fold in PRP19's WD40 domain is comprised of seven blades and is asymmetrical due to a slight distortion in blades one and seven. The region around blade five is highly conserved and is necessary for interaction between PRP19 and Cwc2, another splicing factor found in the NTC. The WD40 domain of PRP19 is found between residues 165 and 503. Its structure was solved in 2010 by X-Ray diffraction at a resolution of 2.6 Angstroms.<ref name="wd40domain"/>
 =Role in Splicing=