Sandbox Reserved 199: Difference between revisions
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/* Solution Structure and Dynamics of Human Pancreatic Ribonuclease<ref> Rico, M. "The Solution Structure and Dynamics of Human Pancreatic Ribonuclease Determined by NMR Spectroscopy Provide Insight into Its Remarkable Biological Activities and Inhib |
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In 1988, Udgaonkar et al. used 2-dimensional 1H NMR to study bovine pancreatic Ribonuclease and examined protein folding dynamics, which supported the framework model protein folding mechanism. | In 1988, Udgaonkar et al. used 2-dimensional 1H NMR to study bovine pancreatic Ribonuclease and examined protein folding dynamics, which supported the framework model protein folding mechanism. | ||
In 1993, Santoro et al. used 3-dimensional 1H NMR to study bovine pancreatic Ribonuclease to compare NMR structures with X-Ray Crystallography structures. | |||
In 2008, Rico et al. used 3-dimensional 1H NMR to study human pancreatic Ribonuclease. They looked at active site conformational changes upon substrate binding, and suggested possible biological implications of their findings. | |||
===Medical Significance=== | ===Medical Significance=== | ||
