Sandbox Reserved 197: Difference between revisions
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== '''Introduction''' == | == '''Introduction''' == | ||
Ribonuclease A is an enzyme involved in catalyzing RNA degradation. The structure of RNase A has been determined through crystallography [http://en.wikipedia.org/wiki/Crystallography] and FABMS [http://en.wikipedia.org/wiki/Fast_atom_bombardment]. RNase A is composed of four anti-parallel β-sheets and | Ribonuclease A is an enzyme involved in catalyzing RNA degradation. The structure of RNase A has been determined through crystallography [http://en.wikipedia.org/wiki/Crystallography] and FABMS [http://en.wikipedia.org/wiki/Fast_atom_bombardment]. RNase A is composed of four anti-parallel β-sheets and three α-helixes. The <scene name='Sandbox_Reserved_197/Active_site/1'>active site</scene> lies within the cleft and houses three residues important for catalysis: His12, His119, and Lys41. Presence of four disulfide bonds and four ''cis'' proline residues greatly effect the structure and folding kinetics of RNase A. | ||
== '''Protein Folding''' == | == '''Protein Folding''' == | ||
