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| ==Chorismate Mutase and Tuberculosis== | | ==Chorismate Mutase and Tuberculosis== |
| Chorismate mutase may be involved in pathogenesis <ref name="pizza" />. Researchers are currently looking into new antimicrobial drugs for diseases such as tuberculosis <ref name="pizza" />. These new drugs would take advantage of the fact that chorismate mutase does not occur in humans to target and treat various forms of tuberculosis < ref name="pizza" />. | | Chorismate mutase may be involved in pathogenesis <ref name="pizza" />. Researchers are currently looking into new antimicrobial drugs for diseases such as tuberculosis <ref name="pizza" />. These new drugs would take advantage of the fact that chorismate mutase and the shikimate pathway do not occur in humans to target and treat various forms of tuberculosis < ref name="pizza" />. |
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| one can take advantage of non-occurance of CMs in humans to try to develop antimicrobial drugs for human pathogens such as tb
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| no func in non-shik pathways like those of macrophages of mammals. target this for TB infection
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| ph is 4.5 om tb macrophage enviro. acidic. | | ph is 4.5 om tb macrophage enviro. acidic. |
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| Mycobacterium tuberculosis (Mtb)1 has developed ingenious
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| mechanisms to survive inside the hostile environment presented
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| by the host and to acquire essential nutrients from this
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| adverse environment (1–3). The emergence of drug-resista
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| strains and synergy with the AIDS virus has further aggravated
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| the disease scenario (4–6). For the development of new
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| therapeutic intervention strategies, there is a need for identification
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| of novel targets that are not only unique to Mtb but
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| blocking of which would either prove lethal to the bacterium or
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| render it extremely susceptible to the host immune response.
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| In this context, understanding the mechanism of action of the
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| aromatic amino acid pathway enzymes of Mtb assumes the
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| utmost importance because most of the corresponding genes
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| have been proven essential for the bacterium and have no
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| human or mammalian counterpart (7, 8). Moreover, amino acid
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| auxotrophs of Mtb do not survive or multiply in macrophages
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| (9, 10), suggesting that these amino acids are not available
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| within the compartment of the macrophage in which the bacteria
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| reside.
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| displayed by another hypothetical protein coded by
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| open reading frame Rv0948c, a novel instance of the
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| existence of two monofunctional chorismate mutase 2222222222222222222222222
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| ==References== | | ==References== |
| <references/> | | <references/> |
