Inositol Monophosphatase: Difference between revisions
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=Inositol Monophosphatase (1dk4)= | =Inositol Monophosphatase (1dk4)= | ||
Inositol Monophosphatse is a heteromdimeric phosphatase. This protein structure is derived from the the methanogen ''Methanococcus jannaschii'' (MJ0109). Curiously this protein shows both Inositol Monophosphate (IMPase) activity as well as Fructose 1,6 Bisphosphatase acivity (FBPase)<ref>PMID:11062561</ref>. This protein has a homolog in another archeabacteria, [[1lbv|''Archaeoglobus fulgidus'']]<ref>PMID:11940584</ref>. | Inositol Monophosphatse is a heteromdimeric phosphatase. This protein structure is derived from the the methanogen ''Methanococcus jannaschii'' (MJ0109). Curiously this protein shows both Inositol Monophosphate (IMPase) activity as well as Fructose 1,6 Bisphosphatase acivity (FBPase)<ref>PMID:11062561</ref>. This protein has a homolog in another archeabacteria, [[1lbv|''Archaeoglobus fulgidus'']]<ref>PMID:11940584</ref>. | ||
{{STRUCTURE_1dk4|PDB=1dk4|SCENE= | {{STRUCTURE_1dk4|PDB=1dk4|SCENE='Sandbox_Reserved_326/Begining/2'}} | ||
__TOC__ | __TOC__ | ||
=''Methanococcus jannaschii''[http://en.wikipedia.org/wiki/Methanocaldococcus]= | =''Methanococcus jannaschii''[http://en.wikipedia.org/wiki/Methanocaldococcus]= | ||
:''M. jannaschii'' are thermophilc methane producing archeabacteria that were discovered in 1983 the manned submersible ALVIN<ref>DOI:10.1007/BF00425213</ref>. They were sampled from the base of a deep sea hydrothermal vent in 2600m of water, local tempurature was 85°C. The complete 1.66 mega base pairs of its genome has been sequenced, about 1738 genes were identified, most of them were determined to be homologous to eukaryotic proteins<ref>DOI:10.1126/science.273.5278.1058</ref>. | :''M. jannaschii'' are thermophilc methane producing archeabacteria that were discovered in 1983 the manned submersible ALVIN<ref>DOI:10.1007/BF00425213</ref>. They were sampled from the base of a deep sea hydrothermal vent in 2600m of water, local tempurature was 85°C. The complete 1.66 mega base pairs of its genome has been sequenced, about 1738 genes were identified, most of them were determined to be homologous to eukaryotic proteins<ref>DOI:10.1126/science.273.5278.1058</ref>. | ||
=Structure= | =Structure= | ||
The general structure of this enzyme is a homodimer. This structure has been crystalized in complex with a phosphate group, and three inhibitory Zn ions per subunit. <scene name='Sandbox_Reserved_326/Blah/2'>reaction site</scene> | |||
<scene name='Sandbox_Reserved_326/Blah/2'>reaction site</scene> | |||
=Function= | =Function= | ||
Inositol monophosphatase activity signalling pathway, increases cytosolic Ca+² | Inositol monophosphatase activity signalling pathway, increases cytosolic Ca+² | ||
