Sandbox reserved 330: Difference between revisions
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{{STRUCTURE_1ne8| PDB=1ne8 | SCENE= }} | {{STRUCTURE_1ne8| PDB=1ne8 | SCENE= }} | ||
==Overview of YdcE== | ==Overview of YdcE== | ||
The Bacilis subtilis YdcE gene encodes an endoribonuclease called EndoA, which is a member of the MazF/PemK family of bacterial toxin and the protein encoded by the gene YdcD is an inhibitor of its activity. EndoA cleaves in a UAC sequence, which is predicted to be a single stranded conformation, and has an overlapping cleavage site specificity with the E.coli homologues. EndoA activity results in cleavage products with a 3’phosphate and 5’OH group, which is typical of degradative RNAses that functions in the absence of divalent cations. | The Bacilis subtilis YdcE gene encodes an endoribonuclease called EndoA, which is a member of the MazF/PemK family of bacterial toxin and the protein encoded by the gene YdcD is an inhibitor of its activity. EndoA cleaves in a UAC sequence, which is predicted to be a single stranded conformation, and has an overlapping cleavage site specificity with the E.coli homologues. EndoA activity results in cleavage products with a 3’phosphate and 5’OH group, which is typical of degradative RNAses that functions in the absence of divalent cations <ref > Pellegrini, O., Mathy, N., Gogos.A., Shapiro, L., Condon, C. The Bacillus subtilis YdcDE operon encodes an endoribonuclease of the MazF/PemK family and its inhibitor. Molecular Microbiology.2005. June;56(5):1139-1148</ref> | ||
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<ref>PMID:14517982</ref> | <ref>PMID:14517982</ref> | ||
<references/> | <references/> | ||
