Sandbox Reserved 350: Difference between revisions
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:Protein: cHuman Coagulation factor V, 1czv <ref name="Pubmed">PMID: 10586886 </ref> | :Protein: cHuman Coagulation factor V, 1czv <ref name="Pubmed">PMID: 10586886 </ref> | ||
='''Introduction'''= | ='''Introduction'''= | ||
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Coagulation Factor V originally studied in 1987 by William H. Kane, Akitada Ichinose, Frederick S. Hagen and Earl W. Davie, out of University of Washington, Seattle. <ref name="Old">PMID: 2827731 </ref> | Coagulation Factor V originally studied in 1987 by William H. Kane, Akitada Ichinose, Frederick S. Hagen and Earl W. Davie, out of University of Washington, Seattle. <ref name="Old">PMID: 2827731 </ref> | ||
[http://en.wikipedia.org/wiki/Coagulation_cascade Coagulation] is a complex cascade of a biological reaction that takes place after an injury causing bleeding, to prevent bleeding; A step of hemostatsis, which faccilitates the formation of fibrin. There approiaxmetly 30 known factors which play a role in this massive cascade response. A possible explannation for the sheer complexity associated with what is knwon about this cascade is that tight regulation for the formation of blood clots are crutial. | [http://en.wikipedia.org/wiki/Coagulation_cascade Coagulation] is a complex cascade of a biological reaction that takes place after an injury causing bleeding, to prevent bleeding; A step of hemostatsis, which faccilitates the formation of fibrin. There approiaxmetly 30 known factors which play a role in this massive cascade response. A possible explannation for the sheer complexity associated with what is knwon about this cascade is that tight regulation for the formation of blood clots are crutial. | ||
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The role of Human Coagulation Factor V is to act as a cofactor along with Factor X and Prothrombin (Factor II, inactive) to form a [http://en.wikipedia.org/wiki/Prothrombinase Prothrombinase] complex activating Prothrobin to Thrombin (FIIa). Thrombin is then able to activate Firinogen (Factor I) into Fibrin (FIa), which connects platelets bound at the site of injury; formation of a clot. | The role of Human Coagulation Factor V is to act as a cofactor along with Factor X and Prothrombin (Factor II, inactive) to form a [http://en.wikipedia.org/wiki/Prothrombinase Prothrombinase] complex activating Prothrobin to Thrombin (FIIa). Thrombin is then able to activate Firinogen (Factor I) into Fibrin (FIa), which connects platelets bound at the site of injury; formation of a clot. | ||
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It is vital for controled blood clot formation based on known human diseases/conditions of irregular clotting which are quiet devastating. Two clear aspects of blood clotting involves either under clotting or excessive clotting. The inability to form a clot leads to excessive bleeding from a minor abration known as [http://en.wikipedia.org/wiki/Haemophilia hemophila]. <ref name="Hemo">PMID: 21453683 </ref> | It is vital for controled blood clot formation based on known human diseases/conditions of irregular clotting which are quiet devastating. Two clear aspects of blood clotting involves either under clotting or excessive clotting. The inability to form a clot leads to excessive bleeding from a minor abration known as [http://en.wikipedia.org/wiki/Haemophilia hemophila]. <ref name="Hemo">PMID: 21453683 </ref> [http://en.wikipedia.org/wiki/Thrombosis Thrombosis] is the second case, where excessive clotting or clotting when no wound is present results in free floating embolisms or thombuses. <ref name="Throm">PMID: 21455860 </ref> Floating free in the blood allows the thrombus to lodge itself within the circulatory system, interferring with orgran downstream of the circulating blood. Unusual blood circulation/clotting by a thrombus are causes of heart attacks, strokes and necrosis of tissue. <ref name="Throm2">PMID: 21359071 </ref> | ||
[http://en.wikipedia.org/wiki/Thrombosis Thrombosis] is the second case, where excessive clotting or clotting when no wound is present results in free floating embolisms or thombuses. <ref name="Throm">PMID: 21455860 </ref> Floating free in the blood allows the thrombus to lodge itself within the circulatory system, interferring with orgran downstream of the circulating blood. Unusual blood circulation/clotting by a thrombus are causes of heart attacks, strokes and necrosis of tissue. <ref name="Throm2">PMID: 21359071 </ref> | |||
{{STRUCTURE_1czv|PDB=1czv|SCENE=}} | {{STRUCTURE_1czv|PDB=1czv|SCENE=}} | ||
