Sandbox Reserved 322: Difference between revisions
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The two types of arginase is found in mammalian, are arginase I (hAI) and arginases II (hAII)<ref name="c"/>. Arginase I is found predominantly in the liver, where it catalyzes the final cytosolic step of the urea cycle<ref name="c"/>. Arginases II is a mitochondrial enzyme that does not appear to function in the urea cycle and is more widely disturbed in numerous tissues, for example kidney, brains, skeletal muscle, mammary gland and penile corpus cavernosum<ref name="c"/>. Recent studies show that ''Plasmodium falciparum'' arginase (PFA) plays a role in systemic depletion of arginine levels, which in turn has been associated with human cerebral malaria pathogenesis<ref name="a"/>. In addition the arginase fold is part of the [http://en.wikipedia.org/wiki/Ureohydrolase ''ureohydrolase''] superfamily, which also includes agmatinase, histone de-acetylase and acetylpolyamine amidohydrolase<ref name="a"/>. | The two types of arginase is found in mammalian, are arginase I (hAI) and arginases II (hAII)<ref name="c"/>. Arginase I is found predominantly in the liver, where it catalyzes the final cytosolic step of the urea cycle<ref name="c"/>. Arginases II is a mitochondrial enzyme that does not appear to function in the urea cycle and is more widely disturbed in numerous tissues, for example kidney, brains, skeletal muscle, mammary gland and penile corpus cavernosum<ref name="c"/>. Recent studies show that ''Plasmodium falciparum'' arginase (PFA) plays a role in systemic depletion of arginine levels, which in turn has been associated with human cerebral malaria pathogenesis<ref name="a"/>. In addition the arginase fold is part of the [http://en.wikipedia.org/wiki/Ureohydrolase ''ureohydrolase''] superfamily, which also includes agmatinase, histone de-acetylase and acetylpolyamine amidohydrolase<ref name="a"/>. | ||
<scene name='Sandbox_Reserved_322/Mn_b/1'> | <scene name='Sandbox_Reserved_322/Mn_b/1'>Mn2+B</scene> | ||
==='''Structure and Function'''=== | ==='''Structure and Function'''=== | ||
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