Sandbox Reserved 324: Difference between revisions
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{{Template:Sandbox_Reserved_BCMB307}} | {{Template:Sandbox_Reserved_BCMB307}} | ||
<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | <!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | ||
='''Human eIF2α (1q8k)'''= | |||
{{STRUCTURE_1q8k| PDB=1q8k | SCENE=Sandbox_Reserved_324/Default2/1}} | {{STRUCTURE_1q8k| PDB=1q8k | SCENE=Sandbox_Reserved_324/Default2/1}} | ||
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=Function= | =Function= | ||
The eIF2α subunit is considered to function primarily as a regulatory element of eIF2<ref name="1q8k"/>. The eIF2α is also the target of many kinases which become actived when the cell undergoes certain stresses<ref name="1q8k"/>. These kinases include PKR which is activated by virus infection, the heme regulated inhibitor(HRI) which is activated by iron deficiency, PERK which is activated by increased amounts of unfloded proteins in the ER, and GCN2 which is activated by amino acid starvation<ref name="1q8k"/>. As well, Ser51 has been identified as a phosphorylation site for these kinases<ref name="1q8k"/>. When phosporylation of Ser51 occurs it results in a strong inhibition of translation initiation<ref name="1q8k"/>. | |||
=References= | =References= | ||
<references/> | <references/> | ||
