Sandbox Reserved 344: Difference between revisions
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=Introduction= | =Introduction= | ||
PhoP is a cytoplasmic response regulator from the two component system PhoP/PhoQ. This system responds mainly to changes in extracellular Mg<sup>2+</sup> concentration and is an important | PhoP is a cytoplasmic response regulator from the two component system PhoP/PhoQ. This system responds mainly to changes in extracellular Mg<sup>2+</sup> concentration and is an important part of the signal pathway leading to a coordinated cell response in gram-negative bacteria such as ''Escherichia coli'' and ''Salmonella enterica''. PhoQ, located across the inner membrane, responds to low Mg<sup>2+</sup> concentration by phosphorylating PhoP. Phosphorylated PhoP forms a homodimer and affects gene expression and other two component systems. Gene regulation is achieved by the increased affinity of the homodimer to the PhoP box, a tandem repeat promoter. The response is organism specific but generally involves survival in low Mg2+ environments and virulence. <ref name = "Bachh2007"> PMID:17545283</ref> | ||
=Structure= | =Structure= | ||
PhoP consists of 2 domains, the regulatory domain and the C-terminal effector domain. | PhoP consists of 2 domains, the regulatory domain and the C-terminal effector domain. | ||
