Sandbox Reserved 344: Difference between revisions
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=====Un-activated form===== | =====Un-activated form===== | ||
:Under normal physiological conditions, unactivated PhoP occurs mainly as a monomer. At higher concentration unactivated PhoP has been shown to dimerize and act similar to activated and dimerized PhoP. Many regulatory domains isolated from members of the OmpR/PhoB family and in their inactive form, crystalize in a form similar to their activated dimers. | :Under normal physiological conditions, unactivated PhoP occurs mainly as a monomer. At higher concentration unactivated PhoP has been shown to dimerize and act similar to activated and dimerized PhoP. Many regulatory domains isolated from members of the OmpR/PhoB family and in their inactive form, crystalize in a form similar to their activated dimers.<ref name = "Bachh2007"/> | ||
=====Activated form===== | =====Activated form===== | ||
:Phosphorylation of the regulatory domain stabilizes dimer formation. | :Phosphorylation of the regulatory domain stabilizes dimer formation. <ref name = "Bachh2007"/> | ||
:BeF<sup>3-</sup>: Phosphoryl analog | :BeF<sup>3-</sup>: Phosphoryl analog | ||
:F1 to Mg<sup>2+</sup> | :F1 to Mg<sup>2+</sup> | ||
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=Importance of PhoP= | =Importance of PhoP= | ||
PhoP/PhoQ plays in key role in certain bacteria becoming virulent. For example, ''Salmonella typhimurium'' becomes avirulent when it carries a phoP mutation.<ref name = "Groisman1989"> PMID:2674945</ref> This makes it a promising target for vaccine and antimicrobial drug development. | PhoP/PhoQ plays in key role in certain bacteria becoming virulent. For example, ''Salmonella typhimurium'' becomes avirulent when it carries a phoP mutation.<ref name = "Groisman1989"> PMID:2674945</ref> This makes it a promising target for vaccine and antimicrobial drug development.<ref name = "Bachh2007"/> | ||
=References= | =References= | ||
<references/> | <references/> | ||
