Sandbox reserved 330: Difference between revisions
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Previous studies of toxin families include MazF, ChpAK, and PemK, which all code for endoribonuclease that activates cellular mRNAs by cleaving them at specific sites. Recently, there is a Bacillus subtilis gene product discovered, EndoA, that is a member of RNAses, which is the gene product of the YdcE gene. This EndoA has similar cleavage pattern specificity as MazF and PemK, with cleavage products of a 3’phosphate and 5’OH group<ref name="Pellegrini"/>. Further study revealed that a coexpression of an upstream gene, YdcD reverses the effects of the YdcE toxin, and thus, this is the first antitoxin | Previous studies of toxin families include MazF, ChpAK, and PemK, which all code for endoribonuclease that activates cellular mRNAs by cleaving them at specific sites. Recently, there is a Bacillus subtilis gene product discovered, EndoA, that is a member of RNAses, which is the gene product of the YdcE gene. This EndoA has similar cleavage pattern specificity as MazF and PemK, with cleavage products of a 3’phosphate and 5’OH group<ref name="Pellegrini"/>. Further study revealed that a coexpression of an upstream gene, YdcD reverses the effects of the YdcE toxin, and thus, this is the first toxin-antitoxin system identified for Bacillus subtilis. However, further research is necessary to determine the functionality of the toxin-antitoxin complex. | ||
