Allen sandbox 1: Difference between revisions
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<scene name='Cory_Tiedeman_Sandbox_1/Mg/3'>Mg 2+'s</scene> at its active site. | <scene name='Cory_Tiedeman_Sandbox_1/Mg/3'>Mg 2+'s</scene> at its active site. | ||
The mechanism of enolase follows 3 steps: | The mechanism of enolase follows 3 steps: | ||
Step 1: The substrate, 2PG, binds to the two <scene name='Cory_Tiedeman_Sandbox_1/Mechanism/4'>Mg2+'s</scene>. The carboxyl group coordinates with the two magnesium ions, which stabilizes the negative charge on the oxygen atom and removes charge from the alpha hydrogen, making it a better leaving group. | Step 1: The substrate, 2PG, binds to the two <scene name='Cory_Tiedeman_Sandbox_1/Mechanism/4'>Mg2+'s</scene>. The carboxyl group coordinates with the two magnesium ions, which stabilizes the negative charge on the oxygen atom and removes charge from the alpha hydrogen, making it a better leaving group. | ||
