Glycogenin: Difference between revisions
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Kim Settle (talk | contribs) New page: [[Image:Glycogen_structure.png|thumb|left|350x350px|alt=Alt text|A cross-sectional view of glycogen with the glycogenin dimer remaining covalently attached to the non-reducing end in the ... |
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[[Image:Glycogen_structure.png|thumb|left|350x350px|alt=Alt text|Figure 1. A cross-sectional view of glycogen with the glycogenin dimer remaining covalently attached to the non-reducing end in the centre of the globule.]] | |||
[[Image:Glycogen_structure.png|thumb|left|350x350px|alt=Alt text|A cross-sectional view of glycogen with the glycogenin dimer remaining covalently attached to the non-reducing end in the centre of the globule.]] | |||
{{STRUCTURE_1ll0| PDB=1ll0 | SCENE= }} | {{STRUCTURE_1ll0| PDB=1ll0 | SCENE= }} | ||
'''Glycogenin''' (Glycogenin glucosyltransferase) is the enzyme responsible for the biosynthesis of glycogen; an important storage form of glucose in the body. It is a unique enzyme in that it is primer, substrate, catalyst, and product of its enzymatic reaction and extension process of glycogen biosynthesis. This is initiated by its ability to transfer glucose from UDP-glucose to form an oligosaccharide of glucose units that is covalently attached to itself at Tyr-194 in a multistep reaction mechanism <ref name="one"> PMID:12051921 </ref>. It is placed in glycosyltransferase family 8 becuase it contains highly conserved motifs that are common to glycosyltransferases such as lipopolysaccharide glucose and galactose transferases and galactinol synthases <ref name="two"> PMID:9345621 </ref>. | '''Glycogenin''' (Glycogenin glucosyltransferase) is the enzyme responsible for the biosynthesis of glycogen; an important storage form of glucose in the body. It is a unique enzyme in that it is primer, substrate, catalyst, and product of its enzymatic reaction and extension process of glycogen biosynthesis. This is initiated by its ability to transfer glucose from UDP-glucose to form an oligosaccharide of glucose units that is covalently attached to itself at Tyr-194 in a multistep reaction mechanism <ref name="one"> PMID:12051921 </ref>. It is placed in glycosyltransferase family 8 becuase it contains highly conserved motifs that are common to glycosyltransferases such as lipopolysaccharide glucose and galactose transferases and galactinol synthases <ref name="two"> PMID:9345621 </ref>. | ||
