Gilman sandbox 1: Difference between revisions
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'''Phosphoglucoisomerase''' (alternatively known as '''phosphoglucose isomerase''' or '''Glucose-6-phosphate isomerase''') are a group of enzymes of the isomerase family ([http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.9 EC 5.3.1.9]), so named for their main function in glycolysis and gluconeogenesis. In both these pathways phosphoglucose isomerase (PGI) is used to inter-convert glucose-6-phosphate and fructose 6-phosphate. This reaction is driven by the relative concentrations of these sugars in the cytoplasmic matrix of the cell <ref>PMID:11371164</ref>. | '''Phosphoglucoisomerase''' (alternatively known as '''phosphoglucose isomerase''' or '''Glucose-6-phosphate isomerase''') are a group of enzymes of the isomerase family ([http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.9 EC 5.3.1.9]), so named for their main function in glycolysis and gluconeogenesis. In both these pathways phosphoglucose isomerase (PGI) is used to inter-convert glucose-6-phosphate and fructose 6-phosphate. This reaction is driven by the relative concentrations of these sugars in the cytoplasmic matrix of the cell <ref>PMID:11371164</ref>. | ||
Phosphoglucoisomerase is also | Phosphoglucoisomerase is also known for a list of activities: | ||
* Neuroleukin (NLK)- nerve growth factor. Secreted by T cells, promotes the survival of certain sensory and embryonic nerve cells. Also used to stimulate the production of immunoglobulin <ref>PMID:3764429</ref>. | * Neuroleukin (NLK)- nerve growth factor. Secreted by T cells, promotes the survival of certain sensory and embryonic nerve cells. Also used to stimulate the production of immunoglobulin <ref>PMID:3764429</ref>. | ||
* Autocrine motility factor (AMF)- product of tumor cells, it promotes cell migration and viewed as a possible cause in cancer metastasis<ref>PMID:12054796</ref>. | * Autocrine motility factor (AMF)- product of tumor cells, it promotes cell migration and viewed as a possible cause in cancer metastasis<ref>PMID:12054796</ref>. | ||
* Maturation factor(MF) <ref>PMID:8639816</ref> | * Maturation factor(MF) <ref>PMID:8639816</ref> | ||
* Myofibril-bound serine protese inhibitor (MBSPI)<ref>PMID:10833440</ref> | * Myofibril-bound serine protese inhibitor (MBSPI)<ref>PMID:10833440</ref> | ||
* PGI is important for metabolism in many different clades, including eukarya, bacteria, and archea. <ref> Hansen T, Schlichting B, Grtozinger J, Swam MK, Davies C, Schonheit P. Mutagentic and catalytically residues of cupin type phosphoglucose isomerase from Archaeoglobus fulgidus. FEBS Journal. 2005; 272(24): 6266-75. </ref>. | |||
=='''Structure'''== | =='''Structure'''== | ||
