Sandbox Reserved 192: Difference between revisions
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=='''Medical Implications'''== | =='''Medical Implications'''== | ||
A recent study published in 2010 revealed that tumor propagation is associated with an imbalance in nucleic acid metabolism. In the blood plasma of patients, there are increased levels of circulating nucleic acids and decreased nuclease activity. The abnormally high levels of circulating nucleic acids is associated with the increased expression and secretion of tumor-derived miRNA and DNA. With increased expression the tumor progresses and the patient has a bad prognosis. | |||
RNase A and DNase I inhibit metastasis by catalyzing metastasis pathomorphosis which is apoptosis, necrosis and destruction of oncocytes (epithelial cells with large amounts of mitochondira). This capability retards the primary tumor growth by 30-40%. The tumor bearing mice received doses of RNase A, DNase I or a mixture of the two and the most significant effect observed was in the mice treated with both enzymes simultaneously. Thus the simultaneous administration of RNase A and DNase I lead to an anti-metastatic effect and results in an almost complete absence in the metastases of the tumor. Further observations suggest that RNase A and DNase I are toxic at high levels. So for effective treatment ultra low doses are required to stay below the level of toxicity. | RNase A and DNase I inhibit metastasis by catalyzing metastasis pathomorphosis which is apoptosis, necrosis and destruction of oncocytes (epithelial cells with large amounts of mitochondira). This capability retards the primary tumor growth by 30-40%. The tumor bearing mice received doses of RNase A, DNase I or a mixture of the two and the most significant effect observed was in the mice treated with both enzymes simultaneously. Thus the simultaneous administration of RNase A and DNase I lead to an anti-metastatic effect and results in an almost complete absence in the metastases of the tumor. Further observations suggest that RNase A and DNase I are toxic at high levels. So for effective treatment ultra low doses are required to stay below the level of toxicity. | ||
