Lu sandbox 1: Difference between revisions
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==Structure== | ==Structure== | ||
The E. coli enzyme complex has a weight of approximately 4600-kD and a diameter of about 300 angstroms. | The E. coli enzyme complex has a weight of approximately 4600-kD and a diameter of about 300 angstroms. The core of the particle is made of 24 E2 proteins arranged in a cube, which is surrounded by 24 E1 proteins and 12 E3 proteins. Pyruvate dehydrogenase (E1) falls within the class of alpha and beta proteins<ref>Protein: Pyruvate dehydrogenase E1-beta, PdhB, C-terminal domain from Bacillus stearothermophilus. (2009). Retrieved from http://scop.mrc-lmb.cam.ac.uk</ref>, containing <scene name='Kenny_Coggins_Sandbox_1/Secondary_structure/1'>both alpha helices and beta sheets</scene>, and its structure in E. coli has been solved to a resolution of 1.85 angstroms. That study found that E1 is a homodimer with a molecular weight of 99474 containing α/β folds and bearing two catalytic sites located at the interface between subunits. Each polypeptide chain of E1 consists of 886 residues<ref name="PMID">PMID:11955070</ref>. The structure shown is the E. coli E1 pyruvate dehydrogenase component, PDB code | ||
[[1l8a]]<ref>Jmol: an open-source Java viewer for chemical structures in 3D. http://www.jmol.org/</ref>. | [[1l8a]]<ref>Jmol: an open-source Java viewer for chemical structures in 3D. http://www.jmol.org/</ref>. | ||
