Lu sandbox 1: Difference between revisions
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These two compounds also activate the pyruvate dehydrogenase kinase associated with the enzyme complex<ref name="book" />. This results in phosphorylation of three different E1 serine residues (Ser 203, Ser 264, Ser 271) in human E1 and enzyme inactivation<ref>PMID:11092882</ref>. Enzyme regulation through phosphorylation by pyruvate dehydrogenase kinase and dephosphorylation pyruvate dehydrogenase phosphatase has been implicated as a target for treating cancer, heart ischemia, and diabetes<ref>PMID:17310282</ref>. | These two compounds also activate the pyruvate dehydrogenase kinase associated with the enzyme complex<ref name="book" />. This results in phosphorylation of three different E1 serine residues (Ser 203, Ser 264, Ser 271) in human E1 and enzyme inactivation<ref>PMID:11092882</ref>. Enzyme regulation through phosphorylation by pyruvate dehydrogenase kinase and dephosphorylation pyruvate dehydrogenase phosphatase has been implicated as a target for treating cancer, heart ischemia, and diabetes<ref>PMID:17310282</ref>. | ||
[[Image: | [[Image:400px-1400x1048_pdh_regulation.png]] | ||
==Kinetics== | ==Kinetics== | ||
