Sandbox Reserved 403: Difference between revisions

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'''Tetanospasmin (TeNT)(Tetanus Neurotoxin)'''
'''Tetanospasmin (TeNT)(Tetanus Neurotoxin)'''


<Structure load='1fv2' size='500' frame='true' align='right' caption='THE HC FRAGMENT OF TETANUS TOXIN COMPLEXED WITH AN ANALOGUE OF ITS GANGLIOSIDE RECEPTOR GT1B' scene='Insert optional scene name here' />
<Structure load='1fv2' size='500' frame='true' align='right' caption= '<scene name='Sandbox_Reserved_403/Secondary_structure/1'>TextToBeDisplayed</scene>' scene='THE HC FRAGMENT OF TETANUS TOXIN COMPLEXED WITH AN ANALOGUE OF ITS GANGLIOSIDE RECEPTOR GT1B' />


== Clostidium tetani ==
== Clostidium tetani ==
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== Tetanospasmin (TeNT) ==
== Tetanospasmin (TeNT) ==


Tetanospasmin is a 150-kDa toxin that is composed of one light chain (50-kDa) and one heavy chain (100-kDa).  The light chain is responsible for the toxicity of the molecule, whereas the heavy chain is responsible for binding the toxin to the axonal membranes.  The heavy chain can also be cleaved into 2 fragments HN and HC.  The HN fragment is responsible for the translocation of the light chain across the axonal membrane, whereas the HC fragment binds to the axonal membrane.
Tetanospasmin is a 150-kDa toxin that is composed of one light chain (50-kDa) and one heavy chain (100-kDa).  The light chain is responsible for the toxicity of the molecule, whereas the heavy chain is responsible for binding the toxin to the axonal membranes.  The heavy chain can also be cleaved into 2 fragments Hn and Hc.  The HN fragment is responsible for the translocation of the light chain across the axonal membrane, whereas the Hc fragment binds to the axonal membrane.
   
   


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Hc has two distinct domains:   
Hc has two distinct domains:   
   
   
1. Jelly-roll (amino end)
1. Jelly-roll (amino end)


2. β-Trefoil (carboxyl end)
2. β-Trefoil (carboxyl end)
[[Image:TeNT.jpg]]


Studies have shown that the β-trefoil domain contains the ganglioside binding sites.
Studies have shown that the β-trefoil domain contains the ganglioside binding sites.
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<scene name='Sandbox_Reserved_403/Secondary_structure/1'>TextToBeDisplayed</scene>


<scene name='Sandbox_Reserved_403/Secondary_structure/2'>The Gal-GalNAc-binding site</scene>
<scene name='Sandbox_Reserved_403/Secondary_structure/2'>The Gal-GalNAc-binding site</scene>
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