2hbh: Difference between revisions
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'''Crystal structure of Vitamin D nuclear receptor ligand binding domain bound to a locked side-chain analog of calcitriol and SRC-1 peptide'''<br /> | '''Crystal structure of Vitamin D nuclear receptor ligand binding domain bound to a locked side-chain analog of calcitriol and SRC-1 peptide'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
2HBH is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio] with XE4 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | 2HBH is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio] with <scene name='pdbligand=XE4:'>XE4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HBH OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: alpha helical sandwich]] | [[Category: alpha helical sandwich]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 15:26:57 2008'' | ||
Revision as of 13:26, 23 January 2008
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Crystal structure of Vitamin D nuclear receptor ligand binding domain bound to a locked side-chain analog of calcitriol and SRC-1 peptide
Overview
The crystal structures of vitamin D nuclear receptor (VDR) have revealed, that all compounds are anchored by the same residues to the ligand binding, pocket (LBP). Based on this observation, a synthetic analog with a locked, side chain (21-nor-calcitriol-20(22),23-diyne) has been synthesized in, order to gain in entropy energy with a predefined active side chain, conformation. The crystal structure of VDR LBD bound to this locked side, chain analogue while confirming the docking provides a structural basis, for the activity of this compound.
About this Structure
2HBH is a Protein complex structure of sequences from Danio rerio with XE4 as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of the vitamin D nuclear receptor ligand binding domain in complex with a locked side chain analog of calcitriol., Rochel N, Hourai S, Perez-Garcia X, Rumbo A, Mourino A, Moras D, Arch Biochem Biophys. 2007 Apr 15;460(2):172-6. Epub 2007 Feb 20. PMID:17346665
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