Sandbox11: Difference between revisions
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<scene name='Sandbox11/Empty_ach_binding_pocket/10'> rotating.</scene> | <scene name='Sandbox11/Empty_ach_binding_pocket/10'> rotating.</scene> | ||
Huperzine A reversible binds with AChE at Ser200 but forms hydrogen bonds with Tyr130, Gly117, and Glu199.<ref>http://www.proteopedia.org/wiki/index.php/AChE_inhibitors_and_substrates_%28Part_II%29<ref> | |||
<scene name='Sandbox11/Huperzine_a_ache_binding_site/5'>Huperzine A bound at SER 200 site, </scene> | <scene name='Sandbox11/Huperzine_a_ache_binding_site/5'>Huperzine A bound at SER 200 site, </scene> | ||
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Decamethonium is similar to acetylcholine in that it contains trimethylammonium cations allowing it to bind to the nicotinic acetylcholine receptor.<ref>http://en.wikipedia.org/wiki/Decamethonium<ref> | Decamethonium is similar to acetylcholine in that it contains trimethylammonium cations allowing it to bind to the nicotinic acetylcholine receptor.<ref>http://en.wikipedia.org/wiki/Decamethonium<ref> | ||
<scene name='Sandbox11/Decamethonium_ache/4'>Decamethonium bound at SER 200 site, </scene> | <scene name='Sandbox11/Decamethonium_ache/4'>Decamethonium bound at SER 200 site, </scene> | ||
<scene name='Sandbox11/Decamethonium_ache/6'>stick wireframe, </scene> | <scene name='Sandbox11/Decamethonium_ache/6'>stick wireframe, </scene> | ||
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Soman binds to Ser200, in the active gorge. After binding the acetylcholinesterase(AChE) catalyzes the cleavage of the ether bond on the carbon side causing irreversible inhibition.<ref>http://www.proteopedia.org/wiki/index.php/AChE_inhibitors_and_substrates<ref> | Soman binds to Ser200, in the active gorge. After binding the acetylcholinesterase(AChE) catalyzes the cleavage of the ether bond on the carbon side causing irreversible inhibition.<ref>http://www.proteopedia.org/wiki/index.php/AChE_inhibitors_and_substrates<ref> | ||
<scene name='Sandbox11/Nerve_agent_ache/3'>Nerve agent GD(soman) at gorge, </scene> | <scene name='Sandbox11/Nerve_agent_ache/3'>Nerve agent GD(soman) at gorge, </scene> | ||
<scene name='Sandbox11/Nerve_agent_ache/2'>stick wireframe, </scene> | <scene name='Sandbox11/Nerve_agent_ache/2'>stick wireframe, </scene> | ||
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Rivastigmine reversible inhibits AChE, binding at the active gorge. The AChE cleaves the rivastigmine into carbamyl moiety and NAP.<ref>http://www.proteopedia.org/wiki/index.php/AChE_inhibitors_and_substrates_%28Part_III%29<ref> | Rivastigmine reversible inhibits AChE, binding at the active gorge. The AChE cleaves the rivastigmine into carbamyl moiety and NAP.<ref>http://www.proteopedia.org/wiki/index.php/AChE_inhibitors_and_substrates_%28Part_III%29<ref> | ||
<scene name='Sandbox11/Rivastigmine_ache/3'>Rivastigmine bound at SER 200 site, </scene> | <scene name='Sandbox11/Rivastigmine_ache/3'>Rivastigmine bound at SER 200 site, </scene> | ||
<scene name='Sandbox11/Rivastigmine_ache/2'>stick wireframe, </scene> | <scene name='Sandbox11/Rivastigmine_ache/2'>stick wireframe, </scene> | ||
