Sandbox 111: Difference between revisions
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Amantadine binds with high affinity to a site in the M2 protein spanning five residues: Leu 26, Val 27, Ala 30, Ser 31, and Gly 34. This high affinity is seen at pH’s closer to neutral. In lower pH’s the protein is only somewhat bound to amantadine. Therefore, when determining the mechanism by which amantadine blocks the channel experiments must be conducted at neutral pH. <scene name='Sandbox_111/Binding/10'>Binding of amantadine</scene> to the M2 protein is illustrated for viewing of the bonds. | Amantadine binds with high affinity to a site in the M2 protein spanning five residues: Leu 26, Val 27, Ala 30, Ser 31, and Gly 34. This high affinity is seen at pH’s closer to neutral. In lower pH’s the protein is only somewhat bound to amantadine. Therefore, when determining the mechanism by which amantadine blocks the channel experiments must be conducted at neutral pH. <scene name='Sandbox_111/Binding/10'>Binding of amantadine</scene> to the M2 protein is illustrated for viewing of the bonds. | ||
When amantadine isn't present, the <scene name='Sandbox_111/No_amantadine/ | When amantadine isn't present, the <scene name='Sandbox_111/No_amantadine/3'>pore</scene> created in the M2 complex is open, allowing viral particles to pass through. In the presence of amantadine, this pore is <scene name='Sandbox_111/Amantadine_present/1'>occluded</scene>, which prevents entry of the viral particles. | ||
'''Additional Features''' | '''Additional Features''' | ||
