Sandbox42: Difference between revisions
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== '''Overall Structure''' == | == '''Overall Structure''' == | ||
To date, the entire X-ray or NMR crystal structure of the <scene name='Sandbox42/Initial/1'>NMDA receptor</scene> has not been produced. However, there are many structural subunits of NMDA that have successfully been crystallized and analyzed which provide some structural information about the NMDA receptor. The architecture of NMDA receptors is modular and is composed of multiple domains with distinct functional roles. The large extracellular region of the receptor is partitioned into two domains: an <scene name='Sandbox42/Atd/1'>amino-terminal domain</scene> (ATD) and a <scene name='Sandbox42/Lbd/2'>ligand-binding domain</scene> (LBD) (7). Each domain has 8 alpha helices and 5 beta sheets. | To date, the entire X-ray or NMR crystal structure of the <scene name='Sandbox42/Initial/1'>NMDA receptor</scene> has not been produced. However, there are many structural subunits of NMDA that have successfully been crystallized and analyzed which provide some structural information about the NMDA receptor. The architecture of NMDA receptors is modular and is composed of multiple domains with distinct functional roles. The large extracellular region of the receptor is partitioned into two domains: an <scene name='Sandbox42/Atd/1'>amino-terminal domain</scene> (ATD) and a <scene name='Sandbox42/Lbd/2'>ligand-binding domain</scene> (LBD) (7). Each domain has 8 <scene name='Sandbox42/Alpha/1'>alpha helices</scene> and 5 <scene name='Sandbox42/Beta/2'>beta sheets</scene>. | ||
The ligand-binding domain of NMDA receptors are heterotetrameric ion channels composed of two copies of the glycine-binding NR1 subunit and two copies of the L-glutamate-binding NR2 subunit. The NR1 subunit is further divided up into splice units while the NR2 subunit has four sub-variants (NR2A-NR2D). The receptor as a whole has four general ligand binding sites (6). | The ligand-binding domain of NMDA receptors are heterotetrameric ion channels composed of two copies of the glycine-binding NR1 subunit and two copies of the L-glutamate-binding NR2 subunit. The NR1 subunit is further divided up into splice units while the NR2 subunit has four sub-variants (NR2A-NR2D). The receptor as a whole has four general ligand binding sites (6). | ||
